<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2006-02-01</periodOfReport>

    <noSecuritiesOwned>1</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001340354</issuerCik>
        <issuerName>Thomas Weisel Partners Group, Inc.</issuerName>
        <issuerTradingSymbol>TWPG</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001349708</rptOwnerCik>
            <rptOwnerName>Manson Mark</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O THOMAS WEISEL PARTNERS GROUP, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>ONE MONTGOMERY STREET, SUITE 3700</rptOwnerStreet2>
            <rptOwnerCity>SAN FRANCISCO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94104</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>DR. Rsch &amp; Co-DR of E. Cst Ops</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable></nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <remarks>No securities are beneficially owned.

Exhibit No. Description
24             Power of Attorney</remarks>

    <ownerSignature>
        <signatureName>/s/ Mark Manson</signatureName>
        <signatureDate>2006-02-01</signatureDate>
    </ownerSignature>
</ownershipDocument>
