X0202 3 2007-07-12 0 0000875320 VERTEX PHARMACEUTICALS INC / MA VRTX 0001349077 Kelly Lisa C/O VERTEX PHARMACEUTICALS INCORPORATED 130 WAVERLY STREET CAMBRIDGE MA 02139 0 1 0 0 SVP, Human Resources Common Stock 7000 D Common Stock 360 I 401(k) Stock Option 33.51 2006-10-31 2016-07-30 Common Stock 30000 D Stock Option 36.30 2007-04-23 2017-01-23 Common Stock 22500 D Includes (i) 4,000 restricted shares granted on July 31, 2006, subject to a repurchase right that lapses in four equal annual installments and (ii) 3,000 restricted shares vesting on January 24, 2011, subject to a repurchase right and to acceleration upon achievement of certain performance-based milestones. Right to buy shares of Common Stock under 2006 Stock and Option Plan, vesting in 16 equal quarterly installments from July 31, 2006. Right to buy shares of Common Stock under 2006 Stock and Option Plan, vesting in 16 equal quarterly installments from January 24, 2007. Valerie L. Andrews, Attorney-In-Fact 2007-07-16