EXHIBIT 107

Calculation of Filing Fee Tables

Form S-8

(Form Type)

22nd Century Group, Inc.

(Exact Name of Registrant as Specified in its Charter)

Table 1: Newly Registered Securities

Security Type	Security Class Title	Fee Calculation Rule	Amount Registered(1)			Proposed Maximum Offering Price Per Unit			Maximum Aggregate Offering Price		Fee Rate		Amount of Registration Fee
Equity	Common Stock, $0.00001 par value per share	Other(2)		5,297,139	(3)	$	4.192	(2)	$	22,205,606.68	$	0.00015310	$	3,399.68
Total Offering Amounts									$	22,205,606.68			$	3,399.68
Total Fee Offsets														—
Net Fee Due													$	3,399.68

(1) Pursuant to Rule 416 promulgated under the Securities Act of 1933, as amended (the “Securities Act”), this Registration Statement on Form S-8 (this “Registration Statement”) shall also cover any additional shares of 22nd Century Group, Inc.’s (the “Registrant”) common stock, par value of $0.00001 per share (“Common Stock”) that become issuable under the Registrant’s Amended and Restated 2021 Omnibus Incentive Plan, as amended (the “Plan”), by reason of any stock dividend, stock split, reverse stock split, recapitalization, reclassification, merger, split-up, reorganization, consolidation or other similar transaction effected without the Registrant’s receipt of consideration, which results in an increase in the number of shares of outstanding Common Stock.

(2) Estimated solely for the purpose of calculating the amount of the registration fee pursuant to Rules 457(c) and (h) of the Securities Act of 1933, as amended, based upon the average of the high and low prices of Common Stock as reported on the Nasdaq Capital Market on January 30, 2025.

(3) Represents 5,297,139 additional shares of Common Stock that were authorized for issuance under the Plan as a result of the 1-for-135 reverse stock split effected December 17, 2024.