<?xml version="1.0" encoding="UTF-8"?>
<edgarSubmission xmlns="http://www.sec.gov/edgar/thirteenffiler" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>13F-NT</submissionType>
    <filerInfo>
      <liveTestFlag>LIVE</liveTestFlag>
      <flags>
        <confirmingCopyFlag>false</confirmingCopyFlag>
        <returnCopyFlag>false</returnCopyFlag>
        <overrideInternetFlag>false</overrideInternetFlag>
      </flags>
      <filer>
        <credentials>
          <cik>0001347769</cik>
          <ccc>XXXXXXXX</ccc>
        </credentials>
      </filer>
      <periodOfReport>03-31-2020</periodOfReport>
    </filerInfo>
  </headerData>
  <formData>
    <coverPage>
      <reportCalendarOrQuarter>03-31-2020</reportCalendarOrQuarter>
      <filingManager>
        <name>COLUMN GROUP L P</name>
        <address>
          <com:street1>1700 OWENS STREET</com:street1>
          <com:street2>SUITE 500</com:street2>
          <com:city>SAN FRANCISCO</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>94158</com:zipCode>
        </address>
      </filingManager>
      <reportType>13F NOTICE</reportType>
      <form13FFileNumber>028-16410</form13FFileNumber>
      <otherManagersInfo>
        <otherManager>
          <cik>0001606074</cik>
          <form13FFileNumber>028-16412</form13FFileNumber>
          <name>Svennilson Peter</name>
        </otherManager>
      </otherManagersInfo>
      <provideInfoForInstruction5>N</provideInfoForInstruction5>
    </coverPage>
    <signatureBlock>
      <name>Peter Svennilson</name>
      <title>Managing Partner, The Column Group GP, LP</title>
      <phone>(415) 865-2050</phone>
      <signature>/s/ Peter Svennilson</signature>
      <city>San Francisco</city>
      <stateOrCountry>CA</stateOrCountry>
      <signatureDate>05-05-2020</signatureDate>
    </signatureBlock>
  </formData>
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