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Loss per Share (Details) - shares
9 Months Ended
Sep. 30, 2018
Sep. 30, 2017
Loss per Share    
Total shares issuable upon exercise or conversion (in shares) 60,987,786 35,662,151
Stock Options    
Loss per Share    
Total shares issuable upon exercise or conversion (in shares) 33,300,688 28,810,791
Warrants    
Loss per Share    
Total shares issuable upon exercise or conversion (in shares) 21,705,426 869,688
Senior Convertible Notes    
Loss per Share    
Total shares issuable upon exercise or conversion (in shares) 5,981,672 5,981,672