CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS (USD $) In Thousands, except Share data, unless otherwise specified	3 Months Ended	9 Months Ended
Sep. 30, 2014	Sep. 30, 2013	Sep. 30, 2014	Sep. 30, 2013
Costs and Expenses:
Research and development	$ 20,946	$ 10,782	$ 58,724	$ 34,181
General and administrative	2,506	2,692	7,963	8,773
Loss from Operations	(23,452)	(13,474)	(66,687)	(42,954)
Other Income/(Loss)
Interest and investment income -net	19	14	47	48
State R&D tax credits			83
Change in fair value of derivative instruments-warrants	425	(77)	1,404	633
Total Other Income	444	(63)	1,534	681
Net Loss	$ (23,008)	$ (13,537)	$ (65,153)	$ (42,273)
Weighted Average Common Shares Outstanding
Basic and Diluted (in shares)	94,738,048	90,182,115	93,631,115	83,548,398
Net Loss per Common Share, Basic and Diluted
Net Loss per Common Share, Basic and Diluted (in dollars per share)	$ (0.24)	$ (0.15)	$ (0.70)	$ (0.51)

Represents the amount of tax credits attributable to state research and development.

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The amount of net income or loss for the period per each share in instances when basic and diluted earnings per share are the same amount and reported as a single line item on the face of the financial statements. Basic earnings per share is the amount of net income or loss for the period per each share of common stock or unit outstanding during the reporting period. Diluted earnings per share includes the amount of net income or loss for the period available to each share of common stock or common unit outstanding during the reporting period and to each share or unit that would have been outstanding assuming the issuance of common shares or units for all dilutive potential common shares or units outstanding during the reporting period.

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The aggregate total of expenses of managing and administering the affairs of an entity, including affiliates of the reporting entity, which are not directly or indirectly associated with the manufacture, sale or creation of a product or product line.

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Amount after accretion (amortization) of discount (premium), and investment expense, of interest income and dividend income on nonoperating securities.

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Net income after adjustments for dividends on preferred stock (declared in the period) and/or cumulative preferred stock (accumulated for the period).

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The aggregate amount of income or expense from ancillary business-related activities (that is to say, excluding major activities considered part of the normal operations of the business).

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The net result for the period of deducting operating expenses from operating revenues.

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The costs incurred in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, excluding in-process research and development acquired in a business combination consummated during the period. Excludes software research and development, which has a separate concept.

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The net change in the difference between the fair value and the carrying value, or in the comparative fair values, of derivative instruments, including options, swaps, futures, and forward contracts, held at each balance sheet date, that was included in earnings for the period.

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Average number of shares or units issued and outstanding that are used in calculating basic and diluted earnings per share (EPS).

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