Commitments and Contingencies (Details) (USD $)	12 Months Ended				0 Months Ended	12 Months Ended					12 Months Ended			0 Months Ended		12 Months Ended	0 Months Ended		12 Months Ended
	Dec. 31, 2013	Dec. 31, 2012	Dec. 31, 2011	Dec. 31, 2013 Employment and Consulting Agreements Gary S. Jacob, Ph.D multiplier	Jan. 02, 2014 Employment and Consulting Agreements Gary S. Jacob, Ph.D Subsequent Event	Dec. 31, 2013 Employment and Consulting Agreements Gary S. Jacob, Ph.D Maximum	Dec. 31, 2013 Employment and Consulting Agreements Gary S. Jacob, Ph.D Minimum	Dec. 31, 2013 Employment and Consulting Agreements Gabriele M. Cerrone multiplier	Dec. 31, 2010 Employment and Consulting Agreements Gabriele M. Cerrone day	Oct. 06, 2010 Employment and Consulting Agreements Gabriele M. Cerrone	Dec. 31, 2013 Employment and Consulting Agreements Gabriele M. Cerrone Maximum	Dec. 31, 2013 Employment and Consulting Agreements Gabriele M. Cerrone Minimum	Dec. 31, 2013 Employment and Consulting Agreements Bernard F. Denoyer multiplier	Jan. 02, 2014 Employment and Consulting Agreements Bernard F. Denoyer Subsequent Event	Dec. 31, 2013 Employment and Consulting Agreements Bernard F. Denoyer Maximum	Dec. 31, 2013 Employment and Consulting Agreements Kunwar Shailubhai multiplier	Jan. 02, 2014 Employment and Consulting Agreements Kunwar Shailubhai Subsequent Event	Dec. 31, 2013 Employment and Consulting Agreements Kunwar Shailubhai Maximum	Dec. 31, 2013 Lease agreements 20th floor of 420 Lexington Avenue, New York	Dec. 31, 2013 Lease agreements Small laboratory and several offices at Bucks County Biotechnology Center in Doylestown, Pennsylvania
Commitments and contingencies
Current base salary per year				$ 425,000	$ 500,000			$ 425,000						$ 219,000			$ 300,000
Cash bonus, as a percentage of base salary per year based on meeting certain performance objectives and bonus criteria						50.00%					50.00%
Enterprise value of the joint venture for receipt of realization bonus							250,000,000					250,000,000
License fees contracted to receive receipt of realization bonus							50,000,000					50,000,000
Multiplier percentage of enterprise value of joint venture or license fees of an out license for bonus realization				0.50%				0.50%
Enterprise value at the time of the merger or sale for receipt of bonus							400,000,000					400,000,000
Beneficial ownership of surviving entity after consummation of the merger, owned by stockholders prior to consummation of the merger or sale for receipt of bonus (as a percent)						20.00%	20.00%				20.00%	20.00%
Period after the merger or sale when enterprise value equals or exceed specified amount				12 months				12 months
Enterprise value at the time of merger or sale or twelve months after merger or sale for receipt of bonus							250,000,000					250,000,000
Multiplier percentage of enterprise value on fulfillment of specified criteria for bonus receipt				2.50%				2.50%
Period preceding termination for which average monthly base salary paid or accrued will be paid to individual as severance payment				3 months				3 months					3 months
Expense compensation multiplier of the sum of average base salary during the specified period preceding the termination				12				12
Period preceding the termination for which an average base salary will be paid to individual as expense compensation				3 months				3 months								3 months
Period following the termination date for extension of the exercise period of options				10 years				10 years					10 years			10 years
Period following termination for which cost of medical insurance will be paid				12 months				12 months					12 months			12 months
Lump sum payment on employment termination upon change of control				2,286,000				1,942,500					318,563			617,000
Renewal term of agreement													1 year			1 year
Cash bonus, percentage of base salary at the discretion of the Compensation Committee of the Board of Directors															25.00%			30.00%
Threshold required for realization bonus to be accrued on the cumulative gross proceeds of financing transactions, achieved										20,000,000
Realization bonus expense									1,211,912
Gross proceeds from financing transaction on cumulative basis subsequent to a specific date for deferment of bonus payment									30,000,000
Number of business days after termination of agreement without cause or good reason for deferment of bonus payment									10
Severance payment multiplier of the average monthly base compensation paid or accrued during specified period preceding the termination								12					12			12
Monthly rate of lease																			35,000	2,800
Rent expense	$ 617,000	$ 301,000	$ 239,000