X0306 4 2013-01-17 1 0001347613 SYNERGY PHARMACEUTICALS, INC. SGYP 0001307746 Shailubhai Kunwar C/O SYNERGY PHARMACEUTICALS INC. 420 LEXINGTON AVENUE, SUITE 1609 NEW YORK NY 10170 0 1 0 0 Chief Scientific Officer Stock Options 1.50 2013-01-17 4 A 0 4498 A 2003-06-13 2013-06-13 Common Stock 4498 992024 D Stock Options 1.50 2013-01-17 4 A 0 17990 A 2014-04-06 Common Stock 17990 1010014 D Stock Options 1.53 2013-01-17 4 A 0 13493 A 2015-10-10 Common Stock 13493 1023507 D Stock Options 0.66 2013-01-17 4 A 0 22488 A 2017-04-12 Common Stock 22488 1045995 D Pursuant to the Agreement and Plan of Merger, dated as of July 20, 2012, as amended October 15, 2012, by and between Synergy Pharmaceuticals Inc ("Synergy") and Callisto Pharmaceuticals, Inc. ("Callisto"), Callisto merged with and into Synergy (the "Merger"). Upon the effective time of the Merger, each share of Callisto common stock was cancelled and exchanged for .1799 shares of Synergy common stock (the "Exchange Ratio"). Each stock option exercisable for shares of Callisto common stock that is outstanding at the effective time of the Merger was assumed by Synergy and converted into a stock option to purchase the number of shares of Synergy's common stock that the holder would have received if such holder had exercised such stock option for shares of Callisto common stock prior to the Merger and exchanged such shares for Synergy common stock in accordance with the Exchange Ratio. 8,995 options vested on each of June 13, 2004 and December 13, 2004. 6,747 options vested on each of October 10, 2006 and 2007. 7,496 options vested on April 12, 2008, 2009 and 2010, respectively. /s/ Kunwar Shailubhai 2013-01-22