Summary of Significant Accounting Policies - Net Product Sales (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Revenue from External Customer [Line Items]
Net product sales	$ 64,390	$ 67,899	$ 124,582	$ 130,568
HETLIOZ® net product sales
Revenue from External Customer [Line Items]
Net product sales	41,188	44,509	78,219	83,852
Fanapt® net product sales
Revenue from External Customer [Line Items]
Net product sales	$ 23,202	$ 23,390	$ 46,363	$ 46,716