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Stock-Based Compensation (Tables)
 6 Months Ended
Jun. 30, 2022
Share-based Payment Arrangement [Abstract]  
Summary of Option Activity
A summary of option activity under the Plans for the six months ended June 30, 2022 follows:
 
(in thousands, except for share and per share amounts)Number of
Shares		Weighted Average
Exercise Price at
Grant Date		Weighted Average
Remaining Term
(Years)		Aggregate
Intrinsic
Value
Outstanding at December 31, 20213,721,148 $14.16 5.77$11,327 
Granted745,028 11.10 
Exercised(30,000)4.15 172 
Outstanding at June 30, 20224,436,176 13.72 6.052,640 
Exercisable at June 30, 20222,975,219 13.53 4.642,486 
Vested and expected to vest at June 30, 20224,198,438 13.75 5.872,615 
Summary of RSU Activity
A summary of RSU activity under the Plans for the six months ended June 30, 2022 follows:
Number of
Shares
Weighted
Average
Grant Date Fair Value
Unvested at December 31, 20211,764,740 $17.27 
Granted897,374 11.26 
Forfeited(33,205)14.44 
Vested(622,107)17.55 
Unvested at June 30, 20222,006,802 14.54 
Stock-Based Compensation Expense
Stock-based compensation expense recognized for the three and six months ended June 30, 2022 and 2021 was comprised of the following:
 
 Three Months EndedSix Months Ended
(in thousands)June 30,
2022		June 30,
2021		June 30,
2022		June 30,
2021
Research and development$899 $957 $2,059 $2,077 
Selling, general and administrative2,931 2,783 6,549 5,572 
Total stock-based compensation expense$3,830 $3,740 $8,608 $7,649 
Black-Scholes-Merton Option Pricing Model for Employee and Director Stock Options Granted Assumptions used in the Black-Scholes-Merton option pricing model for employee and director stock options granted during the six months ended June 30, 2022 and 2021 were as follows:
 
 Six Months Ended
June 30, 2022June 30, 2021
Expected dividend yield0 %0 %
Weighted average expected volatility46 %46 %
Weighted average expected term (years)6.055.98
Weighted average risk-free rate2.03 %0.75 %