Commitments and Contingencies - CFTR Activators and Inhibitors - Additional Information (Details) - CFTR Activators and Inhibitors - USD ($) $ in Thousands	3 Months Ended		61 Months Ended
	Mar. 31, 2022	Dec. 31, 2021	Mar. 31, 2022	Dec. 31, 2020
Commitments and Contingencies [Line Items]
Future percentage of royalty payments based net sales	single-digit
Development and milestone obligations paid to third party			$ 1,600
Developmental Milestone
Commitments and Contingencies [Line Items]
Possible future milestone payments	$ 11,900
Future Regulatory Approval and Sales Milestones
Commitments and Contingencies [Line Items]
Possible future milestone payments	33,000
Development and Milestone Payment, Conclusion of Clinical Studies
Commitments and Contingencies [Line Items]
Possible future milestone payments	1,100
Development and Milestone Payment, Conclusion of Clinical Studies | Maximum
Commitments and Contingencies [Line Items]
Possible future milestone payments	$ 3,200
Development And Milestone Payment, Conclusion Of Phase I Study
Commitments and Contingencies [Line Items]
Payments made for milestone under license agreements		$ 350
Milestone obligations under license agreements				$ 350