Summary of Significant Accounting Policies - Net Product Sales (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Revenue from External Customer [Line Items]
Net product sales	$ 60,192	$ 62,669
HETLIOZ® net product sales
Revenue from External Customer [Line Items]
Net product sales	37,031	39,343
Fanapt® net product sales
Revenue from External Customer [Line Items]
Net product sales	$ 23,161	$ 23,326