X0306 4 2022-07-28 0 0001347178 Vanda Pharmaceuticals Inc. VNDA 0001806596 Moran Kevin Patrick 2200 PENNSYLVANIA AVENUE SUITE 300E WASHINGTON DC 20037 0 1 0 0 SVP, CFO & Treasurer Common Stock 2022-07-28 4 S 0 2239 10.97 D 117452 D Common Stock 635 I By Wife Represents shares of the Issuer's common stock sold to satisfy tax obligations relating to the acquisition of shares of the Issuer's common stock in connection with the settlement of the vested portion of RSUs. Such sale was executed pursuant to an irrevocable election made by the Reporting Person during an open trading window under a program approved by the Compensation Committee of the Issuer's Board of Directors. /s/ Kevin Patrick Moran 2022-08-01