X0306 4 2022-06-13 0 0001347178 Vanda Pharmaceuticals Inc. VNDA 0001802653 Mitchell Stephen Ray C/O VANDA PHARMACEUTICALS INC. 2200 PENNSYLVANIA AVENUE, SUITE 300E WASHINGTON DC 20037 1 0 0 0 Common Stock 2022-06-13 4 S 0 2700 9.4789 D 6515 D Represents shares of the Issuer's common stock sold to satisfy tax obligations relating to the acquisition of shares of the Issuer's common stock in connection with the settlement of the vested portion of RSUs. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $9.431 to $9.53, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote (2) to this Form 4. /s/ Stephen Ray Mitchell 2022-06-14