X0306 4 2022-06-02 0 0001347178 Vanda Pharmaceuticals Inc. VNDA 0001307935 Watkins Thomas 1221 GULF SHORE BLVD N #303 NAPLES FL 34102 1 0 0 0 Common Stock 2022-06-02 4 M 0 15000 4.15 A 69505 D Common Stock 2022-06-02 4 S 0 6441 9.902 D 63064 D Stock Option (Right to Buy) 4.15 2022-06-02 4 M 0 15000 0.00 D 2022-06-13 Common Stock 15000 0 D Represents shares of the Issuer's common stock sold to satisfy the exercise price of the stock options, which were scheduled to expire June 13, 2022 as reflected in this Form 4. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $9.90 to $9.92, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote (2) to this Form 4. The option vested in 12 equal monthly installments beginning on July 14, 2012. /s/ H. Thomas Watkins 2022-06-03