X0306 4 2021-09-09 0 0001347178 Vanda Pharmaceuticals Inc. VNDA 0001802653 Mitchell Stephen Ray C/O VANDA PHARMACEUTICALS INC. 2200 PENNSYLVANIA AVENUE, SUITE 300E WASHINGTON DC 20037 1 0 0 0 Common Stock 2021-09-09 4 M 0 5985 10.57 A 15200 D Common Stock 2021-09-09 4 M 0 13124 12.70 A 28324 D Common Stock 2021-09-09 4 S 0 19109 16.7448 D 9215 D Stock Option (right to buy) 10.57 2021-09-09 4 M 0 5985 0.00 D 2030-06-10 Common Stock 5985 0 D Stock Option (right to buy) 12.70 2021-09-09 4 M 0 13124 0.00 D 2030-02-13 Common Stock 13124 21876 D A portion of the shares was sold to satisfy the exercise price of the stock options. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $16.53 to $16.97, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote (2) to this Form 4. This option vested and became exercisable with respect to 100% of the option shares on June 11, 2021. The option vested with respect to 25% of the underlying shares on February 14, 2021, with the balance vesting in equal monthly installments over the next 36 months of continuous service thereafter, provided the Reporting Person provides continuous service to the Issuer through the applicable vesting date. /s/ Stephen Ray Mitchell 2021-09-13