X0306 4 2019-03-01 0 0001347178 Vanda Pharmaceuticals Inc. VNDA 0001652023 Reverberi Gian Piero 2200 PENNSYLVANIA AVENUE SUITE 300E WASHINGTON DC 20037 0 1 0 0 SVP & Chief Commercial Officer Common Stock 2019-03-01 4 S 0 438 20.165 D 168432 D Common Stock 2019-03-04 4 S 0 443 19.916 D 167989 D Represents shares of the Issuer's common stock sold to satisfy tax obligations relating to the acquisition of shares of the Issuer's common stock in connection with the settlement of the vested portion of RSUs. Such sale was executed pursuant to an irrevocable election made by the Reporting Person during an open trading window under a program approved by the Compensation Committee of the Issuer's Board of Directors. /s/ Gian Piero Reverberi 2019-03-04