X0306 4 2019-02-27 0 0001347178 Vanda Pharmaceuticals Inc. VNDA 0001355537 Polymeropoulos Mihael Hristos 2200 PENNSYLVANIA AVENUE SUITE 300E WASHINGTON DC 20037 1 1 0 0 President and CEO Common Stock 2019-02-27 4 A 0 60000 A 1223636 D Employee Stock Option (Right to Buy) 20.62 2019-02-27 4 A 0 140000 0.00 A 2029-02-26 Common Stock 140000 140000 D Represents shares of common stock underlying a time-based restricted stock unit award ("RSU"). The RSU vests in four (4) equal annual installments with the first annual vest taking place on March 1, 2020, provided the Reporting Person remains continuously employed by the Issuer through each annual vesting date. Vested shares will be delivered on the First Permissible Trading Day (as defined in the RSU Agreement) that occurs on or after the day when the RSUs vest. The option vests in forty-eight (48) equal monthly installments from the date of grant, provided the Reporting Person remains continuously employed by the Issuer through each vesting date. /s/ Mihael Hristos Polymeropoulos 2019-03-01