X0306 4 2015-05-21 0 0001347178 Vanda Pharmaceuticals Inc. VNDA 0001355537 Polymeropoulos Mihael Hristos 2200 PENNSYLVANIA AVENUE SUITE 300E WASHINGTON DC 20037 1 1 0 0 President and CEO Common Stock 2015-05-21 4 M 0 35806 0.331 A 584727 D Common Stock 2015-05-21 4 S 0 17157 10.3332 D 567570 D Common Stock 2015-05-22 4 M 0 359815 0.331 A 927385 D Common Stock 2015-05-22 4 S 0 169238 10.3644 D 758147 D Employee Stock Option (Right to Buy) 0.331 2015-05-21 4 M 0 35806 0.00 D 2015-09-28 Common Stock 35806 359815 D Employee Stock Option (Right to Buy) 0.331 2015-05-22 4 M 0 359815 0.00 D 2015-09-28 Common Stock 359815 0 D Represents shares of common stock sold to cover the payment of the option exercise price and to satisfy tax obligations relating to exercise of the option, which was scheduled to expire on September 28, 2015. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $10.33 to $10.35, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in footnotes (2) and (3) to this Form 4. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $10.22 to $10.46, inclusive. Became exercisable with respect to 25% of the shares on September 28, 2006, and with respect to an additional 2.08333% of the aggregate shares each month thereafter. /s/ Mihael Hristos Polymeropoulos 2015-05-26