X0306 4 2015-03-09 0 0001347178 Vanda Pharmaceuticals Inc. VNDA 0001263499 DUGAN RICHARD W 298 BEACON CIRCLE BOALSBURG PA 16827 1 0 0 0 Common Stock 2015-03-09 4 M 0 10574 4.7329 A 10574 D Common Stock 2015-03-09 4 S 0 4804 10.6859 D 5770 D Nonqualified Stock Option (Right to Buy) 4.73 2015-03-09 4 M 0 10574 0.00 D 2015-12-29 Common Stock 10574 0 D The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $10.66 to $10.73, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in footnote (1) to this Form 4. Reflects the converted exercise price of each option share pursuant to the 1-for-3.309755 reverse stock split which occurred immediately following the effectiveness of the registration statement covering the issuer's initial public offering. The Form 3 originally filed on April 12, 2006 inadvertently listed 10,571 shares of Common Stock instead of 10,574 shares of Common Stock. Exercisable with respect to 660 shares immediately. Exercisable with respect to an additional 2.08333% of the aggregate option share total each month thereafter. /s/ Richard W. Dugan 2015-03-10