144 0001355537 XXXXXXXX LIVE 0001347178 Vanda Pharmaceuticals Inc. 001-34186 c/o Vanda Pharmaceuticals Inc. 2200 Pennsylvania Ave. Suite 300E Washington DC 20037 202-374-3400 Mihael H. Polymeropoulos Officer Chairman of the Board Common Stock Merrill Lynch

1152 15th Street, N.W. Suite 6000 Washington DC 20005

156235 1276976 59108030 03/02/2026 NASDAQ Common Stock 03/01/2026 Vesting/Settlement of Restricted Stock Units Issuer N 156235 03/01/2026 Compensation Y 03/02/2026 /s/ Mihael H. Polymeropoulos