X0202 4/A 2006-11-17 2006-11-21 0 0001347178 Vanda Pharmaceuticals Inc. VNDA 0001352876 Ramsay David Russ 47 HULFISH STREET SUITE 310 PRINCETON NJ 08542 1 0 0 0 Common Stock 2006-11-17 4 S 0 252666 14.25 D 3129539 I See Footnote Common Stock 2006-11-17 4 S 0 17334 14.25 D 214666 I See Footnote Common Stock 2006-11-20 4 S 0 46790 15.29 D 3082749 I See Footnote Common Stock 2006-11-20 4 S 0 3210 15.29 D 211456 I See Footnote The reportable securities are owned directly by Care Capital Investments II, L.P. and indirectly by Care Capital II, LLC as general partner of Care Capital Investments II, L.P. The reporting person is a managing member of Care Capital II, LLC. The reporting person disclaims beneficial ownership of the reportable securities and this report shall not be deemed an admission that he is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of its pecuniary interest therein. The reportable securities are owned directly by Care Capital Offshore Investments II, L..P. and indirectly by Care Capital II, LLC as general partner of Care Capital Offshore Investments II, L.P. The reporting person is a managing member of Care Capital II, LLC. The reporting person disclaims beneficial ownership of the reportable securities and this report shall not be deemed an admission that he is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of its pecuniary interest therein. * This amendment is being filed to correct the amount of securities beneficially owned following the reported transaction. /s/ David R. Ramsay 2006-11-22