X0202 4 2006-11-17 0 0001347178 Vanda Pharmaceuticals Inc. VNDA 0001212648 CARE CAPITAL II LLC 47 HULFISH STREET SUITE 310 PRINCETON NJ 08542 0 0 1 0 0001223011 CARE CAPITAL INVESTMENTS II LP 47 HULFISH STREET SUITE 310 PRINCETON NJ 08542 0 0 1 0 0001357403 Care Capital Offshore Investments II LP 47 HULFISH STREET SUITE 310 PRINCETON NJ 08542 0 0 1 0 0001204568 LESCHLY JAN 47 HULFISH STREET SUITE 310 PRINCETON NJ 08542 0 0 1 0 Common Stock 2006-11-17 4 S 0 252666 14.25 D 4573541 I See Footnote Common Stock 2006-11-17 4 S 0 17334 14.25 D 313705 I See Footnote Common Stock 2006-11-20 4 S 0 46790 15.29 D 4526751 I See Footnote Common Stock 2006-11-20 4 S 0 3210 15.29 D 310495 I See Footnote The reportable securities are owned directly by Care Capital Investments II, L.P. and indirectly by Care Capital II, LLC as general partner of Care Capital Investments II, L.P. Care Capital II, LLC disclaims beneficial ownership of the reportable securities and this report shall not be deemed an admission that Care Capital II, LLC is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extend of its pecuniary interest therein. Jan Leschly is a managing member of Care Capital II, LLC. Mr. Leschly disclaims beneficial ownership of the reportable securities and this report shall not be deemed an admission that he is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of his pecuniary interest therein. The reportable securities are owned directly by Care Capital Offshore Investments II, L.P. and indirectly by Care Capital II, LLC as general partner of Care Capital Offshore Investments II, L.P. Care Capital II, LLC disclaims beneficial ownership of the reportable securities and this report shall not be deemed an admission that Care Capital II, LLC is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extend of its pecuniary interest therein. Jan Leschly is a managing member of Care Capital II, LLC. Mr. Leschly disclaims beneficial ownership of the reportable securities and this report shall not be deemed an admission that he is the beneficial owner of such securities for purposes of Section 16 or for any other purpose, except to the extent of his pecuniary interest therein. /s/ David R. Ramsay, Authorized Signatory 2006-11-21