<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<headerData>
<submissionType>144</submissionType>
<filerInfo>
<filer>
<filerCredentials>
<cik>0001806596</cik>
<ccc>XXXXXXXX</ccc>
</filerCredentials>
</filer>
<liveTestFlag>LIVE</liveTestFlag>
</filerInfo>
</headerData>
<formData>
<issuerInfo>
<issuerCik>0001347178</issuerCik>
<issuerName>Vanda Pharmaceuticals Inc.</issuerName>
<secFileNumber>001-34186</secFileNumber>
<issuerAddress>
<street1 xmlns="http://www.sec.gov/edgar/common">2200 Pennsylvania Avenue NW</street1>
<street2 xmlns="http://www.sec.gov/edgar/common">Suite 300E</street2>
<city xmlns="http://www.sec.gov/edgar/common">Washington</city>
<stateOrCountry xmlns="http://www.sec.gov/edgar/common">DC</stateOrCountry>
<zipCode xmlns="http://www.sec.gov/edgar/common">20037</zipCode>
</issuerAddress>
<issuerContactPhone>202-734-3400</issuerContactPhone>
<nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Moran Kevin Patrick</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
<relationshipsToIssuer>
<relationshipToIssuer>Officer</relationshipToIssuer>
</relationshipsToIssuer>
</issuerInfo>
<securitiesInformation>
<securitiesClassTitle>Common Stock</securitiesClassTitle>
<brokerOrMarketmakerDetails>
<name>Merrill Lynch</name>
<address>
<street1 xmlns="http://www.sec.gov/edgar/common">1152 15th Street, N.W.</street1>
<street2 xmlns="http://www.sec.gov/edgar/common">Suite 6000</street2>
<city xmlns="http://www.sec.gov/edgar/common">Washington</city>
<stateOrCountry xmlns="http://www.sec.gov/edgar/common">DC</stateOrCountry>
<zipCode xmlns="http://www.sec.gov/edgar/common">20005</zipCode>
</address>
</brokerOrMarketmakerDetails>
<noOfUnitsSold>2251</noOfUnitsSold>
<aggregateMarketValue>13327</aggregateMarketValue>
<noOfUnitsOutstanding>58198273</noOfUnitsOutstanding>
<approxSaleDate>07/29/2024</approxSaleDate>
<securitiesExchangeName>NASDAQ</securitiesExchangeName>
</securitiesInformation>
<securitiesToBeSold>
<securitiesClassTitle>Common Stock</securitiesClassTitle>
<acquiredDate>07/29/2024</acquiredDate>
<natureOfAcquisitionTransaction>Vesting/Settlement of Restricted Stock Units</natureOfAcquisitionTransaction>
<nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
<isGiftTransaction>N</isGiftTransaction>
<amountOfSecuritiesAcquired>2251</amountOfSecuritiesAcquired>
<paymentDate>07/29/2024</paymentDate>
<natureOfPayment>Compensation</natureOfPayment>
</securitiesToBeSold>
<nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
<noticeSignature>
<noticeDate>07/29/2024</noticeDate>
<signature>/s/ Kevin Patrick Moran</signature>
</noticeSignature>
</formData>
</edgarSubmission>
