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Stock-Based Compensation - Summary of Assumptions Used in Black-Scholes Option Pricing Model (Detail)
3 Months Ended
Mar. 31, 2018
Mar. 31, 2017
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]    
Risk-free interest rate, minimum 2.51% 2.07%
Risk-free interest rate, maximum 2.71% 2.57%
Expected volatility, minimum   75.30%
Expected volatility 85.90%  
Expected volatility, maximum   80.70%
Expected dividend yield 0.00% 0.00%
Employee Options [Member]    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]    
Expected life of options (in years) 6 years 3 months 6 years 3 months
Nonemployee Options [Member]    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]    
Expected life of options (in years)   10 years