Income Taxes - Schedule of Significant Components of Company's Deferred Tax Assets and Liabilities (Detail) - USD ($) $ in Thousands	Dec. 31, 2024	Dec. 31, 2023
Income Taxes
Valuation allowance	$ (200,656)	$ (192,791)
Deferred tax assets:
Net operating loss carryforwards	122,727	123,739
Federal and state tax credits	32,016	31,245
Stock-based compensation expense	1,619	3,855
Intangible asset amortization	34,823	33,162
Sales of future royalties and milestones	8,952
Other	519	2,101
Deferred tax assets	200,656	194,102
Deferred tax liabilities:
Other		(1,311)
Deferred tax liabilities		(1,311)
Net deferred tax asset	$ 0	$ 0