Income Taxes - Schedule of Reconciliation of Income Taxes Computed Using U.S. Federal Statutory Rate to that Reflected in Operations (Detail)	12 Months Ended
	Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2022
Income Taxes
Income taxes using U.S. federal statutory rate	21.00%	21.00%	21.00%
State income taxes, net of federal benefit	(5.05%)	5.30%	(1.00%)
Impact of R&D tax credit on effective tax rate	2.59%	3.68%	4.91%
Impact of foreign tax credit on effective tax rate	(0.29%)
Stock option shortfalls and cancellations	(4.88%)	(1.22%)	(3.33%)
Permanent items and other	(0.65%)	(0.89%)	(1.86%)
Change in valuation allowance	(11.11%)	(27.34%)	(19.88%)
Provision to return	(1.05%)	(0.53%)	0.16%
Total	0.56%	0.00%	0.00%