CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2022
Operating activities
Net loss	$ (70,867)	$ (118,513)	$ (85,474)
Adjustments to reconcile net loss to net cash used in operating activities:
Stock-based compensation expense	8,929	13,730	17,734
Non-cash interest expense on liability related to sales of future royalties and milestones, net of issuance costs accretion	8,473	604
Impairment of long-lived assets	4,274	0	0
Inventory write-down	2,963
Depreciation and amortization	192	259	248
Noncash lease expense	766	2,075	1,422
(Accretion)/amortization of available-for-sale marketable securities, net	(543)	(400)	264
Changes in operating assets and liabilities:
Accounts receivable, net - related party	2,358	495	(3,260)
Inventory	(1,042)	(438)	201
Income tax receivable	697
Other receivables	(1,034)	(59)	(41)
Prepaid expenses	7,625	8,113	(13,748)
Accounts payable and accrued expenses	(21,439)	3,275	5,679
Operating lease liabilities	(4,363)	(1,918)	(1,755)
Reimbursement of lease incentive	2,094	807
Other		(108)
Net cash used in operating activities	(60,917)	(92,078)	(78,730)
Investing activities
Proceeds from maturities of available-for-sale marketable securities	82,000	155,441	220,435
Proceeds from redemptions of available-for-sale marketable securities, at par		4,000	4,000
Purchases of available-for-sale marketable securities	(32,213)	(113,605)	(95,685)
Purchases of property and equipment	(1,046)	(2,375)	(43)
Net cash provided by investing activities	48,741	43,461	128,707
Financing activities
Payments to royalty purchase and sale agreement	(3,604)
Proceeds from royalty purchase and sale agreement, net of $1.0 million of issuance costs		36,474
Net proceeds from sales of common stock under open market sales agreement		1,117
Proceeds from the exercise of stock options		560	311
Net cash (used in) provided by financing activities	(3,604)	38,151	311
Net (decrease) increase in cash, cash equivalents and restricted cash	(15,780)	(10,466)	50,288
Cash, cash equivalents and restricted cash at beginning of period	53,683	64,149	13,861
Cash, cash equivalents and restricted cash at end of period	37,903	53,683	$ 64,149
Noncash investing and financing activities
Receivable for additional HCR financing earned	2,500
Incremental right-of-use asset in exchange for non-cash lease liability from modification of lease	3,417
Transfer of property and equipment per lease assignment	(3,417)
Initial direct costs included as right-of-use asset from modification of lease	$ 577
Accrual for leasehold improvements		$ 778