Commitments and Contingencies - Additional Information (Detail) $ in Thousands			1 Months Ended		3 Months Ended
	Jul. 28, 2023 USD ($)	May 11, 2023 USD ($)	Jul. 31, 2021	Jul. 31, 2019 agreement	Mar. 31, 2024 USD ($)	Mar. 31, 2023 USD ($)	Feb. 29, 2024 USD ($)	Jan. 31, 2024 USD ($)	Dec. 31, 2023 USD ($)
Other Commitments [Line Items]
Accounts payable and accrued expenses					$ 14,875				$ 25,592
Operating lease liabilities					7,045
Operating lease right-of-use assets					3,826				4,864
Research and development					21,964	$ 24,334
New Corporate Headquarters Office Space
Other Commitments [Line Items]
Lease, annual fixed rent		$ 1,300
Lease, fixed rent, annual increase, percent		2.50%
Option to extend		true
Operating Lease, renewable term		5 years
Discount rate - operating leases		12.83%
Operating lease liabilities	$ 6,672
Lessee, operating lease, incentives	2,900
Operating lease right-of-use assets	$ 6,779
Lease incentives reimbursed							$ 778	$ 947
Operating Lease, expense					269
New Corporate Headquarters Office Space | Secured Overnight Financing Rate (SOFR) Overnight Index Swap Rate
Other Commitments [Line Items]
Lessee, operating lease, discount rate, basis spread on variable rate		7.75%
Lessee, operating lease, discount rate, variable rate basis, floor		2.75%
New Corporate Headquarters Office Space | Research and Development
Other Commitments [Line Items]
Operating Lease, expense					173
New Corporate Headquarters Office Space | General and Administrative
Other Commitments [Line Items]
Operating Lease, expense					96
Patheon and Patheon Manufacturing Services LLC
Other Commitments [Line Items]
Reduced demand payment for manufacturing commitments									$ 1,700
Accounts payable and accrued expenses					246
Old Stamford Operating Lease
Other Commitments [Line Items]
Operating lease cost					0	407
Old Stamford Operating Lease | Research and Development
Other Commitments [Line Items]
Operating lease cost						284
Old Stamford Operating Lease | General and Administrative
Other Commitments [Line Items]
Operating lease cost						123
New Stamford Lease
Other Commitments [Line Items]
Letter of credit amount outstanding					1,500
Non-Exclusive License Agreement | Enteris Biopharma, Inc.
Other Commitments [Line Items]
Payment of milestone payment					$ 0	$ 0
MSA | Patheon and Patheon Manufacturing Services LLC
Other Commitments [Line Items]
Number of related product agreements | agreement				2
API Commercial Supply Agreement - PPL
Other Commitments [Line Items]
Agreement renewal term			5 years