Commitments and Contingencies - Additional Information (Detail) $ in Thousands			1 Months Ended	12 Months Ended
	May 11, 2023 USD ($)	Aug. 31, 2019 USD ($)	Jul. 31, 2019 agreement	Dec. 31, 2023 USD ($)	Dec. 31, 2022 USD ($)	Dec. 31, 2021 USD ($)	Nov. 30, 2023 USD ($)	Jul. 28, 2023 USD ($)
Other Commitments [Line Items]
Research and development				$ 108,510	$ 91,879	$ 82,701
Restricted cash, long-term assets				1,500
Lease incentives reimbursed				808
Operating Lease, renewable term	5 years
Operating lease liabilities				6,088
Lease incentives							$ 1,755
Operating lease right-of-use assets				4,864	1,551
New Stamford Lease
Other Commitments [Line Items]
Restricted cash, long-term assets				$ 1,500
New Corporate Headquarters Office Space
Other Commitments [Line Items]
Lease, annual fixed rent	$ 1,300
Lease, fixed rent, annual increase, percent	2.50%
Option to extend	true
Operating lease liabilities								$ 6,672
Discount rate - operating leases				12.83%
Lease incentives								2,900
Operating lease right-of-use assets								$ 6,779
Operating Lease, expense				$ 524
New Corporate Headquarters Office Space | Secured Overnight Financing Rate (SOFR) Overnight Index Swap Rate
Other Commitments [Line Items]
Lessee, operating lease, discount rate, basis spread on variable rate				7.75%
Lessee, operating lease, discount rate, variable rate basis, floor				2.75%
New Corporate Headquarters Office Space | Research and Development
Other Commitments [Line Items]
Operating Lease, expense				$ 367
New Corporate Headquarters Office Space | General and Administrative
Other Commitments [Line Items]
Operating Lease, expense				157
Original Corporate Headquarters Office Space And Amendment
Other Commitments [Line Items]
Operating lease cost				1,624	1,624	1,624
Original Corporate Headquarters Office Space And Amendment | Research and Development
Other Commitments [Line Items]
Operating Lease, expense				1,137	1,137	1,137
Original Corporate Headquarters Office Space And Amendment | General and Administrative
Other Commitments [Line Items]
Operating Lease, expense				487	487	487
New Stamford Lease
Other Commitments [Line Items]
Restricted cash, long-term assets				1,500
Patheon
Other Commitments [Line Items]
Reduced demand payment for manufacturing commitments				1,700
Non-Exclusive License Agreement | Enteris Biopharma, Inc.
Other Commitments [Line Items]
Upfront fee		$ 8,000
Upfront fee payment, cash		4,000
Upfront fee payment, stock		$ 4,000
Payment of milestone payment				$ 0	5,000	15,000
Research and development					$ 5,000	$ 15,000
License agreement expiration period, first commercial sale		10 years
Agreement termination period for material breach		60 days
Agreement termination period for material breach of a payment obligation		30 days
Agreement termination period for challenged patent rights		30 days
Agreement termination period prior to first regulatory approval		30 days
Agreement termination period after first regulatory approval		60 days
MSA | Patheon and Patheon Manufacturing Services LLC
Other Commitments [Line Items]
Number of related product agreements | agreement			2
MSA | Patheon
Other Commitments [Line Items]
Agreement initial term, expiration date			Dec. 31, 2024
Agreement renewal term			2 years
MSA | Patheon | Minimum [Member]
Other Commitments [Line Items]
Termination notice effective period			18 months
MSA or Product Agreement | Patheon
Other Commitments [Line Items]
Agreement initial term, expiration date			Either party may terminate the MSA or a Product Agreement upon written notice if the other party (1) has failed to remedy a material breach within a specified time or (2) is declared insolvent or bankrupt, voluntarily files a petition of bankruptcy or assigns such agreement for the benefit of creditors. The Company may terminate a Product Agreement (a) upon 90 days’ prior written notice if any governmental agency takes any action that prevents the Company from selling the relevant product in the relevant territory, (b) upon six months’ prior written notice if it does not intend to order manufacturing services due to a product’s discontinuance in the market, or (c) upon 90 days’ prior written notice if it determines that the manufacture or supply of a product likely infringes third-party rights. Patheon may terminate the MSA or a Product Agreement (i) upon six months’ prior written notice if the Company assigns such agreement to an assignee that is unacceptable to Patheon for certain reasons, or (ii) upon 30 days’ prior written notice if, after the first year of commercial sales, the Company forecasts zero volume for 12 months.
Termination notice effective period upon government agency restrictions			90 days
Termination notice effective period upon discontinuance in the market			6 months
Termination notice period if likely infringes on third-party rights			90 days
Termination notice period if assignee is unacceptable			6 months
Termination notice period if zero volume is forecasted after first year of commercial sales			30 days