Income Taxes - Additional Information (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2021
Operating Loss Carryforwards [Line Items]
Percentage of eligible annual research and development credit for cash	65.00%
Benefit from income taxes	$ 0	$ 0	$ 0
Income tax receivable	$ 697	$ 697
Valuation allowance on the deferred tax asset	100.00%	100.00%
Change in valuation allowance	$ 31,977	$ 17,426
Unrecognized tax benefits, related interest and penalties	$ 0	$ 0
Tax examinations, description	tax years 2006 through 2023 remain open to U.S. federal and state tax examinations.
Income taxes using U.S. federal statutory rate	21.00%	21.00%	21.00%
Federal
Operating Loss Carryforwards [Line Items]
Net operating loss carryforwards	$ 467,005
Federal | Earliest Tax Year
Operating Loss Carryforwards [Line Items]
Tax loss carryforwards expiration year	2026
Federal | R&D Tax Credit Carryforwards
Operating Loss Carryforwards [Line Items]
Tax credit carryforwards	$ 27,488
Federal | R&D Tax Credit Carryforwards | Earliest Tax Year
Operating Loss Carryforwards [Line Items]
Tax credit expiration year	2025
State and Local
Operating Loss Carryforwards [Line Items]
Net operating loss carryforwards	$ 473,265
State and Local | Earliest Tax Year
Operating Loss Carryforwards [Line Items]
Tax loss carryforwards expiration year	2027
State and Local | R&D Tax Credit Carryforwards
Operating Loss Carryforwards [Line Items]
Tax credit carryforwards	$ 4,495