Commitments and Contingencies - Additional Information (Detail) $ in Thousands	1 Months Ended		3 Months Ended
	Jul. 31, 2021	Jul. 31, 2019 agreement	Mar. 31, 2023 USD ($)	Mar. 31, 2022 USD ($)	Dec. 31, 2022 USD ($)
Other Commitments [Line Items]
Research and development expense			$ 24,334	$ 21,273
Operating lease liabilities			1,456
Operating lease right-of-use assets			1,175		$ 1,551
Stamford Operating Lease and New Stamford Lease [Member]
Other Commitments [Line Items]
Operating lease cost			407	406
Stamford Operating Lease and New Stamford Lease [Member] | Research and Development [Member]
Other Commitments [Line Items]
Operating lease cost			284	284
Stamford Operating Lease and New Stamford Lease [Member] | General and Administrative [Member]
Other Commitments [Line Items]
Operating lease cost			123	122
Non-Exclusive License Agreement | Enteris Biopharma, Inc. [Member]
Other Commitments [Line Items]
Payment of milestone payment			$ 0	$ 0
Patheon MSA [Member] | Patheon and Patheon Manufacturing Services LLC [Member]
Other Commitments [Line Items]
Number of related product agreements | agreement		2
API Commercial Supply Agreement - PPL [Member]
Other Commitments [Line Items]
Agreement renewal term	5 years