Accounts Payable and Accrued Expenses - Schedule of Accounts Payable and Accrued Expenses (Detail) - USD ($) $ in Thousands	Mar. 31, 2023	Dec. 31, 2022
Accounts Payable and Accrued Expenses
Accounts payable	$ 4,424	$ 9,604
Accrued research projects	5,824	5,200
Accrued compensation and benefits	2,947	5,219
Accrued professional fees and other	2,027	1,517
Total	$ 15,222	$ 21,540