Income Taxes - Additional Information (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Operating Loss Carryforwards [Line Items]
Threshold revenue for exchanging research and development tax credits for cash			$ 70,000
Benefit from income taxes	$ 0	$ 0	$ (691)
Valuation allowance on the deferred tax asset	100.00%	100.00%
Change in valuation allowance	$ 17,426	$ 22,722
Unrecognized tax benefits, related interest and penalties	$ 0	$ 0
Tax examinations, description	tax years 2006 through 2022 remain open to U.S. federal and state tax examinations.
Income taxes using U.S. federal statutory rate	21.00%	21.00%	21.00%
Federal [Member]
Operating Loss Carryforwards [Line Items]
Net operating loss carryforwards	$ 440,195
Federal [Member] | Earliest Tax Year [Member]
Operating Loss Carryforwards [Line Items]
Tax loss carryforwards expiration year	2026
Federal [Member] | R&D Tax Credit Carryforwards [Member]
Operating Loss Carryforwards [Line Items]
Tax credit carryforwards	$ 23,892
Federal [Member] | R&D Tax Credit Carryforwards [Member] | Earliest Tax Year [Member]
Operating Loss Carryforwards [Line Items]
Tax credit expiration year	2025
State and Local [Member]
Operating Loss Carryforwards [Line Items]
Net operating loss carryforwards	$ 347,975
State and Local [Member] | Earliest Tax Year [Member]
Operating Loss Carryforwards [Line Items]
Tax loss carryforwards expiration year	2027
State and Local [Member] | R&D Tax Credit Carryforwards [Member]
Operating Loss Carryforwards [Line Items]
Tax credit carryforwards	$ 2,861