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Income Taxes - Schedule of Reconciliation of Income Taxes Computed Using U.S. Federal Statutory Rate to that Reflected in Operations (Detail)
12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
Income Taxes      
Income taxes using U.S. federal statutory rate 21.00% 21.00% 21.00%
State income taxes, net of federal benefit (1.00%) 7.84% (58.68%)
Tax Cuts and Jobs Act 0.00% 0.00% 0.00%
Impact of R&D tax credit on effective tax rate 4.91% 2.87% (52.06%)
Stock option shortfalls and cancellations (3.33%) (4.74%) 0.35%
Permanent items and other (1.86%) (1.29%) (5.08%)
Change in valuation allowance (19.88%) (25.69%) 84.61%
Provision to return 0.16% 0.01% 0.92%
Non-taxable revenue 0.00% 0.00% 0.00%
Total 0.00% 0.00% (8.94%)