Stock-Based Compensation - Additional Information (Detail) $ / shares in Units, $ in Thousands												1 Months Ended												12 Months Ended
	Oct. 12, 2022 $ / shares shares	Jun. 15, 2022 $ / shares shares	Jun. 02, 2022 $ / shares shares	Feb. 25, 2022 installment $ / shares shares	Dec. 17, 2021 installment $ / shares shares	Nov. 01, 2021 USD ($)	Oct. 29, 2021 tranche $ / shares shares	Jun. 03, 2021 $ / shares shares	Mar. 30, 2021 installment $ / shares shares	Jun. 04, 2020 $ / shares shares	Jun. 04, 2019 $ / shares shares	Oct. 31, 2022 shares	Jun. 30, 2022 shares	Mar. 31, 2022 shares	Feb. 28, 2022 shares	Aug. 31, 2021 shares	Jun. 30, 2021 shares	Mar. 31, 2021 shares	Feb. 28, 2021 shares	Jun. 30, 2020 shares	Apr. 30, 2020 shares	Feb. 29, 2020 installment $ / shares shares	Mar. 31, 2019 $ / shares shares	Dec. 31, 2022 USD ($) $ / shares shares	Dec. 31, 2021 USD ($) $ / shares shares	Dec. 31, 2020 USD ($) $ / shares shares	Dec. 31, 2015 shares	Jan. 01, 2023 shares	Nov. 20, 2019 $ / shares shares
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Common stock, par value | $ / shares																								$ 0.001	$ 0.001
Common stock, shares outstanding																								53,797,341	53,480,812
Common stock, shares issued																								53,797,341	53,480,812
Number of restricted stock units outstanding																								372,513	576,544	235,250
Number of options outstanding																								7,689,449	6,512,280	5,469,393
Options granted																								1,899,919
Employees [Member] | Restricted Stock Units [Member] | Research and Development [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Compensation expense | $																								$ 765	$ 1,201	$ 1,432
Director [Member] | Restricted Stock Units [Member] | General and Administrative [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Compensation expense | $																								$ 628	$ 565	528
Director [Member] | Restricted Stock Units [Member] | General and Administrative [Member] | June 2019 [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Compensation expense | $																										$ 205
Consultants [Member] | Chief Executive Officer
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Options granted																								0	0	0
Employees And Non-Employee Members Of Board Of Directors [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Fair value of options granted | $ / shares																								$ 7.25	$ 12.00	$ 10.33
Options granted																								1,899,919	1,422,750	1,377,850
Employee and Consultant [Member] | Restricted Stock Units [Member] | General and Administrative [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Compensation expense | $																								$ 2,693	$ 2,324	$ 1,167
2019 Inducement Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Common stock, par value | $ / shares																													$ 0.001
2019 Inducement Plan [Member] | Incentive Stock Options [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Options granted																								0	0	0
2019 Inducement Plan [Member] | Maximum [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based compensation arrangement by share-based payment award, number of shares authorized																													300,000
2019 Inducement Plan [Member] | Share-based Payment Arrangement, Employee [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Number of shares available for future issuance																								300,000
2019 Inducement Plan [Member] | Share-based Payment Arrangement, Employee [Member] | Share-Based Compensation Award, Tranche One [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Percentage of vested shares on first anniversary of grant date																								25.00%
2019 Inducement Plan [Member] | Share-based Payment Arrangement, Employee [Member] | Share-based Compensation Award, Tranche Two [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Vesting period of awards granted																								36 months
2019 Inducement Plan [Member] | Share-based Payment Arrangement, Employee [Member] | Share Based Compensation Subsequent Awards [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Vesting period of awards granted																								4 years
2014 Equity Incentive Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Number of stock options that may be granted after the tenth anniversary of the 2014 Plan																								0
Annual increases in number of shares reserved for issuance as a percentage of shares of capital stock outstanding through January 1, 2024																											3.00%
Share-based compensation arrangement by share-based payment award, number of shares authorized																								10,589,103
2014 Equity Incentive Plan [Member] | Time-based Restricted Stock Units [Member] | October 2021 [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Awarded																								147,942
2014 Equity Incentive Plan [Member] | Subsequent Event [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based compensation arrangement by share-based payment award, number of shares authorized																												12,203,023
2014 Equity Incentive Plan [Member] | Maximum [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Term of awards granted																								10 years
2014 Equity Incentive Plan [Member] | Maximum [Member] | Incentive Stock Options [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based compensation arrangement by share-based payment award, number of shares authorized																											30,000,000
2014 Equity Incentive Plan [Member] | Board of Directors Chairman [Member] | Restricted Stock Units [Member] | General and Administrative [Member] | June 2022 [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Compensation expense | $																								$ 100
2014 Equity Incentive Plan [Member] | Board of Directors Chairman [Member] | Chief Executive Officer | Restricted Stock Units [Member] | June 2022 [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Awarded													11,876
2014 Equity Incentive Plan [Member] | Employees [Member] | Performance Restricted Stock Units [Member] | February 2022 [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Awarded				243,000
Restricted stock units, grant date fair value | $ / shares				$ 10.46
Compensation expense | $																								$ 0
Restricted stock units, Forfeited																								214,000
Number of restricted stock units outstanding																								0
2014 Equity Incentive Plan [Member] | Employees [Member] | Performance Restricted Stock Units [Member] | March 2021 [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Awarded									176,000															176,000
Restricted stock units, grant date fair value | $ / shares									$ 20.59
Compensation expense | $																									$ 906
Restricted stock units, vested															37,999	44,002								82,001
Restricted stock units, Forfeited																								93,999
Number of restricted stock units outstanding																								0
2014 Equity Incentive Plan [Member] | Employees [Member] | Performance Restricted Stock Units [Member] | February 2020 [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Awarded																						138,000		138,000
Restricted stock units, grant date fair value | $ / shares																						$ 16.36
Compensation expense | $																									1,256	$ 601
Restricted stock units, vested																		40,000	36,750					113,500
Restricted stock units, Forfeited																								24,500
Number of restricted stock units outstanding																								0
2014 Equity Incentive Plan [Member] | Employees [Member] | Performance Restricted Stock Units [Member] | March 2019 [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Awarded																							215,000
Restricted stock units, grant date fair value | $ / shares																							$ 16.10
Compensation expense | $																										$ 1,543
Restricted stock units, vested																				30,000	65,834					215,000
2014 Equity Incentive Plan [Member] | Employees [Member] | Performance Restricted Stock Units [Member] | Research and Development [Member] | March 2021 [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Compensation expense | $																									329
2014 Equity Incentive Plan [Member] | Employees [Member] | Performance Restricted Stock Units [Member] | Research and Development [Member] | February 2020 [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Compensation expense | $																									524	$ 196
2014 Equity Incentive Plan [Member] | Employees [Member] | Performance Restricted Stock Units [Member] | Research and Development [Member] | March 2019 [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Compensation expense | $																										1,087
2014 Equity Incentive Plan [Member] | Employees [Member] | Performance Restricted Stock Units [Member] | General and Administrative [Member] | Modified November 2021 Awards [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Compensation expense | $																								$ 303
2014 Equity Incentive Plan [Member] | Employees [Member] | Performance Restricted Stock Units [Member] | General and Administrative [Member] | March 2021 [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Compensation expense | $																								729	577
2014 Equity Incentive Plan [Member] | Employees [Member] | Performance Restricted Stock Units [Member] | General and Administrative [Member] | February 2020 [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Compensation expense | $																									732	405
2014 Equity Incentive Plan [Member] | Employees [Member] | Performance Restricted Stock Units [Member] | General and Administrative [Member] | March 2019 [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Compensation expense | $																										456
2014 Equity Incentive Plan [Member] | Employees [Member] | Time-based Restricted Stock Units [Member] | Modified November 2021 Awards [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Restricted stock units, Forfeited													17,333
2014 Equity Incentive Plan [Member] | Employees [Member] | Time-based Restricted Stock Units [Member] | February 2022 [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Vesting period of awards granted				3 years
Awarded				145,170
Restricted stock units, grant date fair value | $ / shares				$ 10.46
Number of equal installment | installment				3
Compensation expense | $																								$ 390
Restricted stock units, vested																								0
Number of options outstanding																								125,170
2014 Equity Incentive Plan [Member] | Employees [Member] | Time-based Restricted Stock Units [Member] | March 2021 [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Vesting period of awards granted									3 years
Awarded									100,000
Restricted stock units, grant date fair value | $ / shares									$ 20.59
Number of equal installment | installment									3
Compensation expense | $																								$ 646	592
Restricted stock units, vested													17,333	33,336										0
Number of restricted stock units outstanding																								31,998
2014 Equity Incentive Plan [Member] | Employees [Member] | Time-based Restricted Stock Units [Member] | Research and Development [Member] | February 2022 [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Compensation expense | $																								$ 161
2014 Equity Incentive Plan [Member] | Employees [Member] | Time-based Restricted Stock Units [Member] | Research and Development [Member] | March 2021 [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Compensation expense | $																								219	166
2014 Equity Incentive Plan [Member] | Employees [Member] | Time-based Restricted Stock Units [Member] | General and Administrative [Member] | Modified March 2021 Awards [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Compensation expense | $																									75
2014 Equity Incentive Plan [Member] | Employees [Member] | Time-based Restricted Stock Units [Member] | General and Administrative [Member] | Modified November 2021 Awards [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Compensation expense | $																								317
2014 Equity Incentive Plan [Member] | Employees [Member] | Time-based Restricted Stock Units [Member] | General and Administrative [Member] | February 2022 [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Compensation expense | $																								229
2014 Equity Incentive Plan [Member] | Employees [Member] | Time-based Restricted Stock Units [Member] | General and Administrative [Member] | March 2021 [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Compensation expense | $																								$ 427	426
2014 Equity Incentive Plan [Member] | Director [Member] | Incentive Stock Options [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Vesting period of awards granted																								3 years
2014 Equity Incentive Plan [Member] | Director [Member] | Restricted Stock Units [Member] | June 2020 [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Vesting period of awards granted										1 year
Awarded										36,000
Restricted stock units, grant date fair value | $ / shares										$ 15.62
Restricted stock units vesting date										Jun. 03, 2021
Restricted stock units, vested																	36,000
2014 Equity Incentive Plan [Member] | Director [Member] | Restricted Stock Units [Member] | June 2019 [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Vesting period of awards granted											1 year
Awarded											24,000
Restricted stock units, grant date fair value | $ / shares											$ 20.47
Restricted stock units, vested																								24,000
2014 Equity Incentive Plan [Member] | Director [Member] | Restricted Stock Units [Member] | General and Administrative [Member] | June 2020 [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Compensation expense | $																								$ 239		323
2014 Equity Incentive Plan [Member] | Director [Member] | Chief Executive Officer | Restricted Stock Units [Member] | June 2020 [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Restricted stock units, vested																	36,000
2014 Equity Incentive Plan [Member] | Executive Officers [Member] | Performance Restricted Stock Units [Member] | March 2019 [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Common stock, shares issued																				30,000	65,834
2014 Equity Incentive Plan [Member] | Executive Officers [Member] | Time-based Restricted Stock Units [Member] | Modified November 2021 Awards [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Compensation expense | $																									73
2014 Equity Incentive Plan [Member] | Executive Officers [Member] | Time-based Restricted Stock Units [Member] | December 2021 [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Vesting period of awards granted					18 months
Awarded					63,573																			52,403
Restricted stock units, grant date fair value | $ / shares					$ 12.45
Number of equal installment | installment					2
Compensation expense | $																								$ 433	20
Restricted stock units, vested																								26,204
2014 Equity Incentive Plan [Member] | Executive Officers [Member] | Time-based Restricted Stock Units [Member] | October 2022 [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Awarded	7,267																							7,267
Restricted stock units, grant date fair value | $ / shares	$ 9.42
Restricted stock units, vested																								0
2014 Equity Incentive Plan [Member] | Executive Officers [Member] | Time-based Restricted Stock Units [Member] | February 2020 [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Vesting period of awards granted																						3 years
Awarded																						98,000		98,000
Restricted stock units, grant date fair value | $ / shares																						$ 16.36
Number of equal installment | installment																						3
Compensation expense | $																								$ 526	607	455
Restricted stock units, vested													16,666		32,666				32,669					82,001
2014 Equity Incentive Plan [Member] | Executive Officers [Member] | Time-based Restricted Stock Units [Member] | Research and Development [Member] | December 2021 [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Compensation expense | $																								$ 210	8
2014 Equity Incentive Plan [Member] | Executive Officers [Member] | Time-based Restricted Stock Units [Member] | Research and Development [Member] | February 2020 [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Compensation expense | $																								175	174	149
2014 Equity Incentive Plan [Member] | Executive Officers [Member] | Time-based Restricted Stock Units [Member] | General and Administrative [Member] | Modified November 2021 Awards [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Compensation expense | $						$ 264
2014 Equity Incentive Plan [Member] | Executive Officers [Member] | Time-based Restricted Stock Units [Member] | General and Administrative [Member] | December 2021 [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Compensation expense | $																								223	12
2014 Equity Incentive Plan [Member] | Executive Officers [Member] | Time-based Restricted Stock Units [Member] | General and Administrative [Member] | October 2022 [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Compensation expense | $																								17
2014 Equity Incentive Plan [Member] | Executive Officers [Member] | Time-based Restricted Stock Units [Member] | General and Administrative [Member] | February 2020 [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Compensation expense | $																								$ 351	433	$ 306
2014 Equity Incentive Plan [Member] | Former Chief Financial Officer [Member] | Performance Restricted Stock Units [Member] | February 2022 [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Restricted stock units, Forfeited													29,000
2014 Equity Incentive Plan [Member] | Former Chief Financial Officer [Member] | Time-based Restricted Stock Units [Member] | February 2022 [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Restricted stock units, Forfeited													20,000
2014 Equity Incentive Plan [Member] | Former Chief Financial Officer [Member] | Time-based Restricted Stock Units [Member] | December 2021 [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Restricted stock units, Forfeited													11,170
2014 Equity Incentive Plan [Member] | Interim Principal Financial and Accounting Officer [Member] | Time-based Restricted Stock Units [Member] | June 2022 [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Awarded		7,500																						7,500
Restricted stock units, grant date fair value | $ / shares		$ 7.94
Restricted stock units, vested																								7,500
2014 Equity Incentive Plan [Member] | Interim Principal Financial and Accounting Officer [Member] | Time-based Restricted Stock Units [Member] | General and Administrative [Member] | June 2022 [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Compensation expense | $																								$ 60
2014 Equity Incentive Plan [Member] | Chief Executive Officer [Member] | Time-based Restricted Stock Units [Member] | October 2021 [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Awarded							147,942
Restricted stock units, grant date fair value | $ / shares							$ 16.83
Number of restricted stock unit tranches | tranche							2
Restricted stock units, vested												35,500												41,442
2014 Equity Incentive Plan [Member] | Chief Executive Officer [Member] | Time-based Restricted Stock Units [Member] | October 2022 [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Restricted stock units, vested												35,500
2014 Equity Incentive Plan [Member] | Chief Executive Officer [Member] | Time-based Restricted Stock Units [Member] | General and Administrative [Member] | October 2021 [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Compensation expense | $																								$ 657	144
2014 Equity Incentive Plan [Member] | Chief Executive Officer [Member] | Share-Based Compensation Award, Tranche One [Member] | Time-based Restricted Stock Units [Member] | October 2021 [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Percentage of vested shares on first anniversary of grant date							25.00%
Awarded							142,000
2014 Equity Incentive Plan [Member] | Chief Executive Officer [Member] | Share-based Compensation Award, Tranche Two [Member] | Time-based Restricted Stock Units [Member] | October 2021 [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Vesting period of awards granted							36 months
Awarded							5,942
2014 Equity Incentive Plan [Member] | Employee And Nonemployee Consultants [Member] | Share-Based Compensation Award, Tranche One [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Percentage of vested shares on first anniversary of grant date																								25.00%
2014 Equity Incentive Plan [Member] | Employee And Nonemployee Consultants [Member] | Share-based Compensation Award, Tranche Two [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Vesting period of awards granted																								36 months
2014 Equity Incentive Plan [Member] | Employee And Nonemployee Consultants [Member] | Share Based Compensation Subsequent Awards [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Vesting period of awards granted																								4 years
2014 Equity Incentive Plan [Member] | Non-employee Directors [Member] | Restricted Stock Units [Member] | June 2022 [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Vesting period of awards granted			1 year
Awarded			59,380																					59,380
Restricted stock units, grant date fair value | $ / shares			$ 8.42
Restricted stock units, vested																								0
2014 Equity Incentive Plan [Member] | Non-employee Directors [Member] | Restricted Stock Units [Member] | June 2021 [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Vesting period of awards granted								1 year
Awarded								43,200																43,200
Restricted stock units, grant date fair value | $ / shares								$ 13.06
Restricted stock units, vested																								43,200
2014 Equity Incentive Plan [Member] | Non-employee Directors [Member] | Restricted Stock Units [Member] | General and Administrative [Member] | June 2022 [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Compensation expense | $																								$ 290
2014 Equity Incentive Plan [Member] | Non-employee Directors [Member] | Restricted Stock Units [Member] | General and Administrative [Member] | June 2021 [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Compensation expense | $																								$ 238	$ 326
2014 Equity Incentive Plan [Member] | Employees And Non-Employee Members Of Board Of Directors [Member] | Restricted Stock Units [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Awarded																								474,193
Restricted stock units, grant date fair value | $ / shares																								$ 10.10
Restricted stock units, vested																								268,222
Restricted stock units, Forfeited																								410,002
Number of restricted stock units outstanding																								372,513	576,544