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Collaboration and Licensing Agreements - Additional Information (Detail) - USD ($)
$ / shares in Units, $ in Thousands
1 Months Ended 3 Months Ended 6 Months Ended
Oct. 15, 2020
May 17, 2018
Oct. 31, 2021
Oct. 31, 2020
May 31, 2018
Jun. 30, 2022
Jun. 30, 2021
Jun. 30, 2022
Jun. 30, 2021
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                  
Revenue from contract with customer           $ 23,003   $ 27,793 $ 1,935
License and Milestone Fees                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                  
Revenue from contract with customer           15,000   15,000 1,192
Collaborative Revenue                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                  
Revenue from contract with customer           8,003   8,003 706
Commercial Supply Revenue                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                  
Revenue from contract with customer               4,790  
Clinical Compound Revenue                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                  
Revenue from contract with customer                 37
Vifor Agreement No 1 [Member]                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                  
Percentage of net profit sharing       60.00%          
Vifor Agreement No 2 [Member]                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                  
Percentage of net profit sharing         50.00%        
Maximum [Member] | Vifor Agreement No 1 [Member]                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                  
Potential sales-based milestone payments     $ 240,000            
Maximum [Member] | Vifor Agreement No 2 [Member]                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                  
Potential milestone payments           440,000   440,000  
Maruishi Pharmaceutical Co., Ltd. [Member] | Clinical Compound Revenue                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                  
Revenue from contract with customer           0 $ 0 0 $ 37
Vifor International Ltd. [Member] | Vifor Agreement No 1 [Member]                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                  
Percentage of net profit sharing       40.00%          
Common stock, shares issued       2,939,552          
Proceeds from the sale of common stock $ 50,000                
Purchase common stock per share amount       $ 17.0094          
Vifor International Ltd. [Member] | Vifor Agreement No 1 [Member] | License [Member]                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                  
Non-refundable, non-creditable upfront payment       $ 100,000          
Vifor International Ltd. [Member] | Vifor Agreement No 2 [Member]                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                  
Common stock, shares issued   1,174,827              
Purchase of common stock value   $ 20,000              
Purchase common stock per share amount   $ 17.024              
Closing prices of company common stock description   over a pre-determined average closing price of the Company’s common stock              
Vifor International Ltd. [Member] | Regulatory Milestones [Member]                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                  
Common stock, shares issued     3,282,391            
Proceeds from the sale of common stock     $ 50,000            
Purchase common stock per share amount     $ 15.23            
Percentage of premium on common stock investment     20.00%            
Stock issuance price measurement period     30 days            
Vifor [Member] | Commercial Supply Revenue                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                  
Revenue from contract with customer               4,790  
Vifor [Member] | Vifor Agreement No 2 [Member]                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                  
Percentage of net profit sharing         50.00%        
Non-refundable, non-creditable upfront payment   $ 50,000              
Vifor [Member] | Vifor Agreement No 2 [Member] | License and Milestone Fees                  
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]                  
Proceeds from milestone payments           $ 15,000   $ 15,000