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Net (Loss) Income per Share - Additional Information (Detail) - shares
1 Months Ended 12 Months Ended
Oct. 15, 2020
Oct. 31, 2021
Dec. 31, 2020
Dec. 31, 2021
Dec. 31, 2019
Number of options outstanding     5,469,393 6,512,280 4,450,517
Number of restricted stock units outstanding     235,250 576,544 119,834
Dilutive stock options     481,254    
Dilutive restricted stock units     20,526    
Vifor International Ltd. [Member] | Regulatory Milestones [Member]          
Stock Issued During Period Shares New Issues   3,282,391      
Percentage of premium on common stock investment 20.00% 20.00%      
Stock issuance price measurement period 30 days 30 days