Income Taxes - Schedule of Significant Components of Company's Deferred Tax Assets and Liabilities (Detail) - USD ($) $ in Thousands	Dec. 31, 2021	Dec. 31, 2020
Income Tax Disclosure [Abstract]
Valuation allowance	$ (143,388)	$ (120,666)
Deferred tax assets:
Net operating loss carryforwards	113,636	93,507
Federal and state tax credits	24,428	19,982
Stock-based compensation expense	5,023	6,732
Other	1,268	2,414
Deferred tax assets	144,355	122,635
Deferred tax liabilities:
Other	(967)	(1,969)
Deferred tax liabilities	$ (967)	$ (1,969)