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Stock-Based Compensation (Tables)
9 Months Ended
Sep. 30, 2020
Summary of Assumptions Used in Black-Scholes Option Pricing Model

Three Months Ended

Nine Months Ended

September 30, 

September 30, 

    

2020

    

2019

    

2020

    

2019

    

Risk-free interest rate

 

0.35% - 0.43%

1.62%

0.35% - 1.57%

1.62% - 2.62%

 

Expected volatility

 

72.6% - 73.3%

71.8%

72.6% - 74.8%

71.8% - 75.2%

 

Expected dividend yield

 

0%

0%

0%

0%

 

Expected life of employee and Board options (in years)

 

6.25

6.25

 

6.25

6.25

 

Summary of Compensation Expense Relating to Stock Options

During the three and nine months ended September 30, 2020 and 2019, the Company recognized compensation expense relating to stock options as follows:

Three Months Ended

Nine Months Ended

September 30, 

September 30, 

    

2020

    

2019

    

2020

    

2019

    

Research and development

$

1,724

$

1,391

$

5,003

$

3,799

General and administrative

 

1,305

 

1,322

 

3,517

 

3,829

Total stock option expense

$

3,029

$

2,713

$

8,520

$

7,628

Summary of Stock Option Activity

A summary of stock option award activity related to employees, non-employee members of the Company’s Board of Directors and non-employee consultants as of and for the nine months ended September 30, 2020 is presented below:

Weighted

Number of

Average Exercise

    

Shares

    

 Price

    

Outstanding, December 31, 2019

 

4,450,517

$

14.73

 

Granted

 

1,165,350

 

16.40

 

Exercised

 

(52,493)

 

12.78

 

Expired

 

(170,581)

 

13.87

 

Forfeited

 

(127,151)

 

16.55

 

Outstanding, September 30, 2020

 

5,265,642

$

15.10

Options exercisable, September 30, 2020

 

2,960,041

Share-based Payment Arrangement, Nonemployee [Member] | Consultants [Member] | Re-Measurement [Member]  
Summary of Assumptions Used in Black-Scholes Option Pricing Model

On January 1, 2019, the Company used the Black-Scholes option valuation model to remeasure the fair value of all outstanding unvested options that had been granted to non-employee consultants in accordance with ASU 2018-07, Compensation – Stock Compensation (Topic 718), Improvements to Non-employee Share-Based Payment Accounting. The range of assumptions used by the Company on January 1, 2019 were as follows:

    

January 1, 2019

Risk-free interest rate

 

2.59% - 2.62%

Expected volatility

 

58.9% - 84.6%

Expected dividend yield

 

0%

Expected life of non-employee options (in years)

 

0.81 - 8.19