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Stock-Based Compensation (Tables)
6 Months Ended
Jun. 30, 2020
Summary of Assumptions Used in Black-Scholes Option Pricing Model

Three Months Ended

Six Months Ended

June 30, 

June 30, 

    

2020

    

2019

    

2020

    

2019

    

Risk-free interest rate

 

0.42% - 0.54%

1.95% - 2.36%

0.42% - 1.57%

1.95% - 2.62%

 

Expected volatility

 

73.73% - 74.80%

73.06% - 73.78%

73.72% - 74.80%

73.06% - 75.19%

 

Expected dividend yield

 

0%

0%

0%

0%

 

Expected life of employee options (in years)

 

6.25

6.25

 

6.25

6.25

 

Expected life of non-employee options (in years)

 

 

 

Summary of Compensation Expense Relating to Stock Options

During the three and six months ended June 30, 2020 and 2019, the Company recognized compensation expense relating to stock options as follows:

Three Months Ended

Six Months Ended

June 30, 

June 30, 

    

2020

    

2019

    

2020

    

2019

    

Research and development

$

1,670

$

1,326

$

3,279

$

2,408

General and administrative

 

1,142

 

1,355

 

2,212

 

2,507

Total stock option expense

$

2,812

$

2,681

$

5,491

$

4,915

Summary of Stock Option Activity

A summary of stock option award activity related to employees, non-employee members of the Company’s Board of Directors and non-employee consultants as of and for the six months ended June 30, 2020 is presented below:

Weighted

Number of

Average Exercise

    

Shares

    

 Price

    

Outstanding, December 31, 2019

 

4,450,517

$

14.73

 

Granted

 

820,350

 

16.04

 

Exercised

 

(24,346)

 

11.34

 

Expired

 

(167,964)

 

13.85

 

Forfeited

 

(113,791)

 

16.21

 

Outstanding, June 30, 2020

 

4,964,766

$

14.96

Options exercisable, June 30, 2020

 

2,756,734

Share-based Payment Arrangement, Nonemployee [Member] | Consultants [Member] | Re-Measurement [Member]  
Summary of Assumptions Used in Black-Scholes Option Pricing Model

On January 1, 2019, the Company used the Black-Scholes option valuation model to remeasure the fair value of all outstanding unvested options that had been granted to non-employee consultants in accordance with ASU 2018-07, Compensation – Stock Compensation (Topic 718), Improvements to Non-employee Share-Based Payment Accounting. The range of assumptions used by the Company on January 1, 2019 were as follows:

    

January 1, 2019

Risk-free interest rate

 

2.59% - 2.62%

Expected volatility

 

58.9% - 84.6%

Expected dividend yield

 

0%

Expected life of non-employee options (in years)

 

0.81 - 8.19