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Stock-Based Compensation - Summary of Compensation Expense Relating to Stock Options (Detail) - USD ($)
1 Months Ended 12 Months Ended
Oct. 31, 2018
Aug. 31, 2017
Dec. 31, 2019
Dec. 31, 2018
Dec. 31, 2017
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]          
Total stock option expense     $ 10,300,000 $ 8,401,000 $ 6,330,000
Compensation expense not yet recognized     $ 22,216,000    
Weighted average period of compensation expense not yet recognized     2 years 8 months 27 days    
Excess tax benefits from stock option activity or stock-based compensation expense recognized in cash flows from operations     $ 0 0 0
Excess tax benefits from stock option activity or stock-based compensation expense recognized in cash flows from financing activities     0 0 0
General and Administrative [Member]          
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]          
Total stock option expense     5,094,000 4,482,000 3,897,000
Research and Development [Member]          
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]          
Total stock option expense     5,206,000 3,919,000 2,433,000
Shareholder Consulting Agreement [Member] | General and Administrative [Member]          
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]          
Total stock option expense     197,000    
Restricted Stock Units [Member] | Director [Member] | General and Administrative [Member]          
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]          
Total stock option expense     287,000    
Restricted Stock Units [Member] | Executive Officers [Member] | General and Administrative [Member]          
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]          
Total stock option expense     1,180,000 1,217,000  
Restricted Stock Units [Member] | Executive Officers [Member] | Research and Development [Member]          
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]          
Total stock option expense     $ 604,000 476,000  
Modified Awards [Member] | Non Employee Stock Option [Member]          
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]          
Accelerate vesting percentage 50.00% 50.00%      
Modification period during which stock options may be exercised   6 months      
Modified Awards [Member] | Non Employee Stock Option [Member] | General and Administrative [Member]          
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]          
Total stock option expense       96,000 $ 537,000
Modified Awards [Member] | Non Employee Stock Option [Member] | Research and Development [Member]          
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]          
Total stock option expense       $ 520,000  
Modified Awards [Member] | Non Employee Stock Option [Member] | Chief Medical Officer [Member]          
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]          
Consulting agreement maturity date May 31, 2019        
Modified Awards [Member] | Non Employee Stock Option [Member] | Chief Financial Officer [Member]          
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]          
Consulting agreement maturity date   Feb. 15, 2018