X0407 4 2023-06-01 0 0001346830 Cara Therapeutics, Inc. CARA 0001237624 VOGELBAUM MARTIN C/O RHO VENTURES 152 WEST 57TH STREET, 23RD FLOOR NEW YORK NY 10019 1 0 0 0 0 Common Stock 2023-06-01 4 A 0 64724 0.00 A 109712 D Stock Option (Right to Buy) 3.09 2023-06-01 4 A 0 89923 0.00 A 2033-06-01 Common Stock 89923 89923 D Represents the number of shares underlying restricted stock units ("RSUs") granted to the Reporting Person pursuant to the Issuer's non-employee director compensation policy. Each RSU represents the contingent right to receive one share of common stock of the Issuer. The RSUs vest on the earlier of (i) June 1, 2024 and (ii) immediately prior to the Issuer's next annual meeting of stockholders following the grant date, in each case, subject to the Reporting Person's continued service as a director through such date. This option was granted to the Reporting Person pursuant to the Issuer's non-employee director compensation policy. The shares underlying the option vest and become exercisable on the earlier of (i) June 1, 2024 and (ii) immediately prior to the Issuer's next annual meeting of stockholders following the grant date, in each case, subject to the Reporting Person's continued service as a director through such date. /s/Darren DeStefano, Attorney-in-Fact 2023-06-05