X0306 4 2018-09-04 0 0001346830 Cara Therapeutics, Inc. CARA 0001597152 Menzaghi Frederique Ph.D. C/O CARA THERAPEUTICS, INC. 4 STAMFORD PLAZA, 107 ELM ST, 9TH FLOOR STAMFORD CT 06902 0 1 0 0 Sr VP-Research & Development Common Stock 2018-09-04 4 S 0 3000 19.81 D 98000 D This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on May 19, 2017. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $19.581 to $20.16, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote (2) to this Form 4. /s/Darren DeStefano, Attorney-in-Fact 2018-09-06