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Collaboration and Licensing Agreements - Additional Information (Detail) - Cara Therapeutics, Inc. - USD ($)
$ in Thousands
1 Months Ended 12 Months Ended
May 17, 2018
Oct. 31, 2020
May 31, 2018
Dec. 31, 2024
Dec. 31, 2023
Collaboration and Licensing Agreements:          
Net proceeds from sales of common stock under open market sales agreement         $ 1,117
Vifor Fresenius Medical Care Renal Pharma Ltd Agreement No 1 [Member]          
Collaboration and Licensing Agreements:          
Percentage of net profit sharing   60.00%      
Potential sales-based milestone payments   $ 240,000      
Number of days to terminate agreement       60 days  
Vifor Fresenius Medical Care Renal Pharma Ltd Agreement No 2 [Member]          
Collaboration and Licensing Agreements:          
Percentage of net profit sharing     50.00%    
License Agreement with Maruishi Pharmaceutical Co. Ltd [Member]          
Collaboration and Licensing Agreements:          
Earned milestone payment         $ 1,449
Affiliated Entity | Vifor Fresenius Medical Care Renal Pharma Ltd Agreement No 1 [Member]          
Collaboration and Licensing Agreements:          
Percentage of net profit sharing   40.00%      
Affiliated Entity | CSL Vifor | Vifor Fresenius Medical Care Renal Pharma Ltd Agreement No 1 [Member]          
Collaboration and Licensing Agreements:          
Percentage of net profit sharing   40.00%      
Affiliated Entity | Vifor Fresenius Medical Care Renal Pharma Ltd | Vifor Fresenius Medical Care Renal Pharma Ltd Agreement No 2 [Member]          
Collaboration and Licensing Agreements:          
Number of days to terminate agreement 60 days        
Termination notice effective period 12 months        
Affiliated Entity | Vifor Fresenius Medical Care Renal Pharma Ltd | Maximum [Member] | Vifor Fresenius Medical Care Renal Pharma Ltd Agreement No 2 [Member]          
Collaboration and Licensing Agreements:          
Potential milestone payments $ 440,000