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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
9 Months Ended 12 Months Ended
Sep. 30, 2024
Sep. 30, 2023
Dec. 31, 2023
Dec. 31, 2022
Dec. 31, 2021
Operating activities          
Net loss $ (63,188) $ (86,176) $ (118,513) $ (85,474) $ (88,441)
Adjustments to reconcile net loss to net cash used in operating activities:          
Stock-based compensation expense 6,575 10,129 13,730 17,734 20,785
Non-cash interest expense on liability related to sales of future royalties and milestones, net of issuance costs accretion 5,852   604    
Impairment of long-lived assets 4,274        
Inventory write-down 2,509   526 34 0
Depreciation and amortization 192 177 259 248 248
Noncash lease expense 766 1,221 2,075 1,422 1,306
Accretion of available-for-sale marketable securities, net (543) (159) (400) 264 861
Changes in operating assets and liabilities:          
Accounts receivable, net - related party 2,330 (91) 495 (3,260)  
Inventory (313) (883) (438) 201 (2,584)
Income tax receivable 697       810
Other receivables (379) (1,186) (59) (41) 102
Prepaid expenses 5,772 3,609 8,113 (13,748) 9,557
Accounts payable and accrued expenses (19,149) 37 3,275 5,679 (1,020)
Operating lease liability (4,363) (1,278) (1,918) (1,755) (1,602)
Reimbursement of lease incentive 2,094   807    
Other   (108) (108)    
Net cash used in operating activities (56,874) (74,708) (92,078) (78,730) (60,087)
Investing activities          
Proceeds from maturities of available-for-sale marketable securities 77,000 118,590 155,441 220,435 173,484
Proceeds from redemptions of available-for-sale marketable securities, at par   4,000 4,000 4,000 20,500
Purchases of available-for-sale marketable securities (32,213) (48,601) (113,605) (95,685) (208,795)
Purchases of property and equipment (1,046) (323) (2,375) (43) (39)
Net cash provided by investing activities 43,741 73,666 43,461 128,707 (4,751)
Financing activities          
Payments to royalty purchase and sale agreement (1,989)        
Net proceeds from sales of common stock under open market sales agreement   1,117 1,117    
Proceeds from the exercise of stock options   559 560 311 1,639
Net cash (used in) provided by financing activities (1,989) 1,676 38,151 311 46,608
Net (decrease) increase in cash, cash equivalents and restricted cash (15,122) 634 (10,466) 50,288 (18,230)
Cash, cash equivalents and restricted cash at beginning of period 53,683 64,149 64,149 13,861 32,091
Cash, cash equivalents and restricted cash at end of period 38,561 64,783 53,683 $ 64,149 $ 13,861
Noncash investing and financing activities          
Incremental right-of-use asset in exchange for non-cash lease liability from modification of lease 3,417        
Initial direct costs included as right-of-use asset from modification of lease $ 577        
Accrual for leasehold improvements   $ 807 $ 778