<SEC-DOCUMENT>0001144204-15-059422-index.html : 20151014
<SEC-HEADER>0001144204-15-059422.hdr.sgml : 20151014
<ACCEPTANCE-DATETIME>20151014161642
ACCESSION NUMBER:		0001144204-15-059422
CONFORMED SUBMISSION TYPE:	SC 13G
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20151014
DATE AS OF CHANGE:		20151014
GROUP MEMBERS:		PETER KOLCHINSKY
GROUP MEMBERS:		RA CAPITAL HEALTHCARE FUND, L.P.

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Zynerba Pharmaceuticals, Inc.
		CENTRAL INDEX KEY:			0001621443
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				260389433
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-88971
		FILM NUMBER:		151158343

	BUSINESS ADDRESS:	
		STREET 1:		80 W. LANCASTER AVENUE
		STREET 2:		SUITE 300
		CITY:			DEVON
		STATE:			PA
		ZIP:			19333
		BUSINESS PHONE:		484-581-7505

	MAIL ADDRESS:	
		STREET 1:		80 W. LANCASTER AVENUE
		STREET 2:		SUITE 300
		CITY:			DEVON
		STATE:			PA
		ZIP:			19333

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Zynerba Pharmeceuticals, Inc.
		DATE OF NAME CHANGE:	20141003

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			RA CAPITAL MANAGEMENT, LLC
		CENTRAL INDEX KEY:			0001346824
		IRS NUMBER:				830406777
		STATE OF INCORPORATION:			MA
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G

	BUSINESS ADDRESS:	
		STREET 1:		20 PARK PLAZA, SUITE 1200
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02116
		BUSINESS PHONE:		617-778-2500

	MAIL ADDRESS:	
		STREET 1:		20 PARK PLAZA, SUITE 1200
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02116
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G
<SEQUENCE>1
<FILENAME>v422148_sc13g.htm
<DESCRIPTION>SC 13G
<TEXT>
Document 1 - file: v422148_sc13g.htm

</DOCUMENT>
</SEC-DOCUMENT>