The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACADIA PHARMACEUTICALS INC COM 004225108 743 30,000 SH   SOLE   30,000 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 129,990 5,250,000 SH Call SOLE   0 0 0
ACHILLION PHARMACEUTICALS IN COM 00448Q201 29,940 3,000,000 SH Call SOLE   0 0 0
ACHILLION PHARMACEUTICALS INC COM 00448Q201 66,866 6,700,000 SH   SOLE   6,700,000 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 1,080 17,600 SH   SOLE   17,600 0 0
AKEBIA THERAPEUTICS INC COM 00972D105 13,220 597,363 SH   SOLE   597,363 0 0
ALIMERA SCIENCES INC COM 016259103 1,321 243,726 SH   SOLE   243,726 0 0
ALKERMES PLC SHS G01767105 823 19,200 SH   SOLE   19,200 0 0
AMGEN INC COM 031162100 829 5,900 SH   SOLE   5,900 0 0
AURIS MED HLDG AG COM H03579101 5,424 940,000 SH   SOLE   940,000 0 0
AVANIR PHARMACEUTICALS INC CL A NEW 05348P401 64,209 5,386,700 SH   SOLE   5,386,700 0 0
BIOCRYST PHARMACEUTICALS COM 09058V103 69,136 7,069,159 SH   SOLE   7,069,159 0 0
BIOGEN IDEC INC COM 09062X103 860 2,600 SH   SOLE   2,600 0 0
BLUEBIRD BIO INC COM 09609G100 26,150 728,812 SH   SOLE   728,812 0 0
CELGENE CORP COM 151020104 825 8,700 SH   SOLE   8,700 0 0
CODEXIS INC COM 192005106 1,175 504,279 SH   SOLE   504,279 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 30,916 2,428,571 SH   SOLE   2,428,571 0 0
DYAX CORP COM 26746E103 79,028 7,809,139 SH   SOLE   7,809,139 0 0
DYNAVAX TECHNOLOGIES CORP COM 268158102 17,416 12,179,002 SH   SOLE   12,179,002 0 0
ENANTA PHARMACEUTICALS INC COM 29251M106 9,893 250,000 SH   SOLE   250,000 0 0
KERYX BIOPHARMACEUTICALS INC COM 492515101 814 59,200 SH   SOLE   59,200 0 0
KYTHERA BIOPHARMACEUTICALS COM 501570105 745 22,750 SH   SOLE   22,750 0 0
MERRIMACK PHARMACEUTICALS INC COM 590328100 1,022 116,400 SH   SOLE   116,400 0 0
NEWLINK GENETICS CORP COM 651511107 643 30,000 SH   SOLE   30,000 0 0
NOVAVAX INC COM 670002104 21,130 5,067,083 SH   SOLE   5,067,083 0 0
OCERA THERAPEUTICS INC COM 67552A108 2,046 417,476 SH   SOLE   417,476 0 0
OPHTHOTECH CORP COM 683745103 22,927 588,941 SH   SOLE   588,941 0 0
PTC THERAPEUTICS INC COM 69366J200 1,135 25,800 SH   SOLE   25,800 0 0
PUMA BIOTECHNOLOGY INC COM 74587V107 740 3,100 SH   SOLE   3,100 0 0
REGENERON PHARMACEUTICALS COM 75886F107 883 2,450 SH   SOLE   2,450 0 0
REPLIGEN CORP COM 759916109 896 45,000 SH   SOLE   45,000 0 0
SANGAMO BIOSCIENCES INC COM 800677106 13,160 1,220,209 SH   SOLE   1,220,209 0 0
SANGAMO BIOSCIENCES INC COM 800677106 64,710 6,000,000 SH Call SOLE   0 0 0
SCYNEXIS INC COM 811292101 6,208 840,000 SH   SOLE   840,000 0 0
SUNESIS PHARMACEUTICALS INC COM NEW 867328601 34,767 4,869,261 SH   SOLE   4,869,261 0 0
T2 BIOSYSTEMS INC COM 89853L104 2,496 138,002 SH   SOLE   138,002 0 0
TENAX THERAPEUTICS INC COM 88032L100 9,182 2,336,375 SH   SOLE   2,336,375 0 0
TG THERAPEUTICS INC COM 88322Q108 22,040 2,065,571 SH   SOLE   2,065,571 0 0
THERAPEUTICSMD INC COM 88338N107 16,028 3,454,332 SH   SOLE   3,454,332 0 0
VERSARTIS INC COM 92529L102 17,072 898,993 SH   SOLE   898,993 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 1,044 9,300 SH   SOLE   9,300 0 0
VICAL INC COM 925602104 6,132 5,475,419 SH   SOLE   5,475,419 0 0
WAFERGEN BIO-SYSTEMS INC COM PAR$ 93041P308 2,436 560,000 SH   SOLE   560,000 0 0
XENCOR INC COM 98401F105 11,627 1,248,923 SH   SOLE   1,248,923 0 0
ZAFGEN INC COM 98885E103 14,403 732,960 SH   SOLE   732,960 0 0
ZS PHARMA INC COM 98979G105 22,145 564,483 SH   SOLE   564,483 0 0