The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
5 01 ACQUISITION CORP COM CL A 33836P105 7,388 750,000 SH   SOLE   750,000 0 0
89BIO INC COM 282559103 18,721 4,965,769 SH   SOLE   4,965,769 0 0
ACHILLES THERAPEUTICS PLC SPONSORED ADS 00449L102 14,743 5,014,687 SH   SOLE   5,014,687 0 0
ACLARIS THERAPEUTICS INC COM 00461U105 31,339 1,817,808 SH   SOLE   1,817,808 0 0
ACUMEN PHARMACEUTICALS INC COM 00509G209 38,204 9,770,773 SH   SOLE   9,770,773 0 0
AEROVATE THERAPEUTICS INC COM 008064107 151,479 8,263,982 SH   SOLE   8,263,982 0 0
AKOUOS INC COM 00973J101 10,836 2,281,249 SH   SOLE   2,281,249 0 0
ALLOVIR INC COM 019818103 9,724 1,440,525 SH   SOLE   1,440,525 0 0
AN2 THERAPEUTICS INC COM 037326105 55,257 3,666,663 SH   SOLE   3,666,663 0 0
ARYA SCIENCES ACQUISITN CLASS A ORD SHS G31658100 9,710 1,000,000 SH   SOLE   1,000,000 0 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101 888,169 7,567,900 SH   SOLE   7,567,900 0 0
ASTRIA THERAPEUTICS INC COM 04635X102 8,469 1,262,193 SH   SOLE   1,262,193 0 0
AVIDITY BIOSCIENCES INC COM 05370A108 40,032 2,167,391 SH   SOLE   2,167,391 0 0
BCLS ACQUISITION CORP COM CL A G0904B105 12,338 1,250,000 SH   SOLE   1,250,000 0 0
BELLUS HEALTH INC NEW COM NEW 07987C204 70,384 10,230,274 SH   SOLE   10,230,274 0 0
BIOGEN INC COM 09062X103 153,111 727,024 SH   SOLE   727,024 0 0
BIOMEA FUSION INC COM 09077A106 2,230 500,000 SH   SOLE   500,000 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105 7,174 2,589,904 SH   SOLE   2,589,904 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 70,675 2,075,000 SH   SOLE   2,075,000 0 0
CENTESSA PHARMACEUTICALS PLC SPONSORED ADS 152309100 32,087 3,577,094 SH   SOLE   3,577,094 0 0
CENTURY THERAPEUTICS INC COM 15673T100 11,508 914,094 SH   SOLE   914,094 0 0
CHEMOCENTRYX INC COM 16383L106 28,980 1,155,964 SH   SOLE   1,155,964 0 0
CHINOOK THERAPEUTICS INC COM 16961L106 16,360 1,000,000 SH   SOLE   1,000,000 0 0
COMPASS THERAPEUTICS INC COM 20454B104 730 532,958 SH   SOLE   532,958 0 0
CONCERT PHARMACEUTICALS INC COM 206022105 10,223 3,033,603 SH   SOLE   3,033,603 0 0
CONNECT BIOPHARMA HLDGS LTD ADS 207523101 21,113 6,991,003 SH   SOLE   6,991,003 0 0
CUE HEALTH INC COM 229790100 4,838 750,000 SH   SOLE   750,000 0 0
CULLINAN ONCOLOGY INC COM 230031106 3,665 350,000 SH   SOLE   350,000 0 0
CVRX INC COM 126638105 1,647 275,000 SH   SOLE   275,000 0 0
CYTEIR THERAPEUTICS INC COM 23284P103 12,631 3,350,506 SH   SOLE   3,350,506 0 0
CYTEK BIOSCIENCES INC COM 23285D109 144,248 13,381,054 SH   SOLE   13,381,054 0 0
DA32 LIFE SCNCE TEC ACQSTN C CLASS A COM 23312M106 14,573 1,500,000 SH   SOLE   1,500,000 0 0
DAY ONE BIOPHARMACEUTICALS I COM 23954D109 60,116 6,060,090 SH   SOLE   6,060,090 0 0
DESIGN THERAPEUTICS INC COM 25056L103 35,314 2,186,636 SH   SOLE   2,186,636 0 0
DICE THERAPEUTICS INC COM 23345J104 99,646 5,208,911 SH   SOLE   5,208,911 0 0
DYNE THERAPEUTICS INC COM 26818M108 27,041 2,805,045 SH   SOLE   2,805,045 0 0
EDGEWISE THERAPEUTICS INC COM 28036F105 25,352 2,613,623 SH   SOLE   2,613,623 0 0
ELIEM THERAPEUTICS INC COM 28658R106 110,336 13,150,849 SH   SOLE   13,150,849 0 0
ENANTA PHARMACEUTICALS INC COM 29251M106 68,633 964,212 SH   SOLE   964,212 0 0
ENTERA BIO LTD SHS M40527109 6,753 2,353,000 SH   SOLE   2,353,000 0 0
EYEPOINT PHARMACEUTICALS INC COM NEW 30233G209 40,952 3,370,506 SH   SOLE   3,370,506 0 0
FORMA THERAPEUTICS HLDGS INC SHS 34633R104 83,808 9,011,651 SH   SOLE   9,011,651 0 0
FRAZIER LIFESCIENCES ACQU CO CL A SHS G3710A121 9,990 1,000,000 SH   SOLE   1,000,000 0 0
GERON CORP COM 374163103 40,972 30,126,299 SH   SOLE   30,126,299 0 0
GH RESEARCH PLC ORDINARY SHARES G3855L106 88,292 4,827,330 SH   SOLE   4,827,330 0 0
GRAPHITE BIO INC COM 38870X104 13,762 2,698,369 SH   SOLE   2,698,369 0 0
GUARDANT HEALTH INC COM 40131M109 31,555 476,380 SH   SOLE   476,380 0 0
HEALTH SCIENCES ACQ CORP 2 ORD SHS G4411D109 6,194 625,000 SH   SOLE   625,000 0 0
ICOSAVAX INC COM 45114M109 41,983 5,963,565 SH   SOLE   5,963,565 0 0
IMMUNOGEN INC COM 45253H101 103,489 21,741,458 SH   SOLE   21,741,458 0 0
INSTIL BIO INC COM 45783C101 52,361 4,870,793 SH   SOLE   4,870,793 0 0
IO BIOTECH INC COM 449778109 9,846 1,857,755 SH   SOLE   1,857,755 0 0
ITEOS THERAPEUTICS INC COM 46565G104 142,147 4,417,259 SH   SOLE   4,417,259 0 0
JANUX THERAPEUTICS INC COM 47103J105 124,337 8,670,644 SH   SOLE   8,670,644 0 0
KALA PHARMACEUTICALS INC COM 483119103 15,007 10,874,613 SH   SOLE   10,874,613 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103 28,453 1,930,322 SH   SOLE   1,930,322 0 0
KINNATE BIOPHARMA INC COM 49705R105 48,014 4,264,144 SH   SOLE   4,264,144 0 0
LARIMAR THERAPEUTICS INC COM 517125100 5,192 1,281,860 SH   SOLE   1,281,860 0 0
LIANBIO SPONSORED ADS 53000N108 28,400 7,655,015 SH   SOLE   7,655,015 0 0
MACROGENICS INC COM 556099109 53,773 6,103,594 SH   SOLE   6,103,594 0 0
MILESTONE PHARMACEUTICALS IN COM 59935V107 14,423 2,246,503 SH   SOLE   2,246,503 0 0
MIRATI THERAPEUTICS INC COM 60468T105 60,378 734,343 SH   SOLE   734,343 0 0
MORPHIC HLDG INC COM 61775R105 11,197 278,874 SH   SOLE   278,874 0 0
NATERA INC COM 632307104 53,303 1,310,289 SH   SOLE   1,310,289 0 0
NKARTA INC COM 65487U108 63,786 5,605,129 SH   SOLE   5,605,129 0 0
NOVAVAX INC COM NEW 670002401 51,024 692,794 SH   SOLE   692,794 0 0
OLEMA PHARMACEUTICALS INC COM 68062P106 2,149 504,505 SH   SOLE   504,505 0 0
ORCHARD THERAPEUTICS PLC ADS 68570P101 6,903 9,694,789 SH   SOLE   9,694,789 0 0
OTONOMY INC COM 68906L105 13,440 5,600,000 SH   SOLE   5,600,000 0 0
PARDES BIOSCIENCES INC COM 69945Q105 44,584 6,175,038 SH   SOLE   6,175,038 0 0
PHASEBIO PHARMACEUTICALS INC COM 717224109 3,762 2,850,000 SH   SOLE   2,850,000 0 0
PMV PHARMACEUTICALS INC COM 69353Y103 35,608 1,710,265 SH   SOLE   1,710,265 0 0
POINT BIOPHARMA GLOBAL INC COM 730541109 71,754 9,003,018 SH   SOLE   9,003,018 0 0
PYXIS ONCOLOGY INC COM 747324101 9,220 2,282,173 SH   SOLE   2,282,173 0 0
RELAY THERAPEUTICS INC COM 75943R102 16,433 549,055 SH   SOLE   549,055 0 0
RELMADA THERAPEUTICS INC COM 75955J402 53,980 2,000,000 SH   SOLE   2,000,000 0 0
RHYTHM PHARMACEUTICALS INC COM 76243J105 56,115 4,871,067 SH   SOLE   4,871,067 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 33,419 2,107,149 SH   SOLE   2,107,149 0 0
RXSIGHT INC COM 78349D107 37,794 3,052,796 SH   SOLE   3,052,796 0 0
SATSUMA PHARMACEUTICALS INC COM 80405P107 22,474 5,914,252 SH   SOLE   5,914,252 0 0
SCPHARMACEUTICALS INC COM 810648105 15,101 2,658,583 SH   SOLE   2,658,583 0 0
SOLID BIOSCIENCES INC COM 83422E105 14,841 12,367,873 SH   SOLE   12,367,873 0 0
SYNLOGIC INC COM 87166L100 16,000 6,666,666 SH   SOLE   6,666,666 0 0
TANGO THERAPEUTICS INC COM 87583X109 17,055 2,250,000 SH   SOLE   2,250,000 0 0
TENAYA THERAPEUTICS INC COM 87990A106 41,837 3,551,508 SH   SOLE   3,551,508 0 0
TRAVERE THERAPEUTICS INC COM 89422G107 126,864 4,922,941 SH   SOLE   4,922,941 0 0
TSCAN THERAPEUTICS INC COM 89854M101 2,861 1,021,764 SH   SOLE   1,021,764 0 0
TYRA BIOSCIENCES INC COM 90240B106 77,430 7,236,454 SH   SOLE   7,236,454 0 0
VAXCYTE INC COM 92243G108 110,636 4,581,203 SH   SOLE   4,581,203 0 0
VERA THERAPEUTICS INC CL A 92337R101 46,183 1,966,084 SH   SOLE   1,966,084 0 0
VERONA PHARMA PLC SPONSORED ADS 925050106 25,449 5,100,000 SH   SOLE   5,100,000 0 0
VERVE THERAPEUTICS INC COM 92539P101 7,081 310,284 SH   SOLE   310,284 0 0
VOR BIOPHARMA INC COM 929033108 67,171 11,120,973 SH   SOLE   11,120,973 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 15,550 7,775,207 SH   SOLE   7,775,207 0 0
WEREWOLF THERAPEUTICS INC COM 95075A107 18,884 4,291,881 SH   SOLE   4,291,881 0 0
XILIO THERAPEUTICS INC COM 98422T100 14,156 2,002,217 SH   SOLE   2,002,217 0 0