<SEC-DOCUMENT>0001104659-22-022759-index.html : 20220214
<SEC-HEADER>0001104659-22-022759.hdr.sgml : 20220214
<ACCEPTANCE-DATETIME>20220214161155
ACCESSION NUMBER:		0001104659-22-022759
CONFORMED SUBMISSION TYPE:	SC 13G/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20220214
DATE AS OF CHANGE:		20220214
GROUP MEMBERS:		PETER KOLCHINSKY
GROUP MEMBERS:		RA CAPITAL HEALTHCARE FUND, L.P.
GROUP MEMBERS:		RAJEEV SHAH

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Orchard Therapeutics plc
		CENTRAL INDEX KEY:			0001748907
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			X0
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-90710
		FILM NUMBER:		22631948

	BUSINESS ADDRESS:	
		STREET 1:		108 CANNON STREET
		CITY:			LONDON
		STATE:			X0
		ZIP:			EC4N 6EU
		BUSINESS PHONE:		011-44-0-203-3846700

	MAIL ADDRESS:	
		STREET 1:		108 CANNON STREET
		CITY:			LONDON
		STATE:			X0
		ZIP:			EC4N 6EU

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Orchard Rx Ltd
		DATE OF NAME CHANGE:	20180802

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			RA CAPITAL MANAGEMENT, L.P.
		CENTRAL INDEX KEY:			0001346824
		IRS NUMBER:				830406777
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A

	BUSINESS ADDRESS:	
		STREET 1:		200 BERKELEY STREET, 18TH FLOOR
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02116
		BUSINESS PHONE:		617-778-2500

	MAIL ADDRESS:	
		STREET 1:		200 BERKELEY STREET, 18TH FLOOR
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02116

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	RA CAPITAL MANAGEMENT, LLC
		DATE OF NAME CHANGE:	20051213
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G/A
<SEQUENCE>1
<FILENAME>tm225316d19_sc13ga.htm
<DESCRIPTION>ORCHARD THERAPEUTICS PLC
<TEXT>
Document 1 - file: tm225316d19_sc13ga.htm

</DOCUMENT>
</SEC-DOCUMENT>